COX-2、c-erbB-2、nm23-H1、PCNA表达与宫颈鳞癌预后的关系  

Prognostic Significance of Expression of COX-2 , c-erbB-2,nm23-H1 and PCNA in Cervical Carcinoma

作　　者：欧阳艳琼[1] 吴绪峰[1] 马莱克[1] 陈惠祯[1] 王玉仁[2] 张志强[2] 

机构地区：[1]武汉大学中南医院妇瘤科,430071 [2]武警湖北总队医院病理科

出　　处：《肿瘤防治研究》2004年第2期84-87,共4页Cancer Research on Prevention and Treatment

基　　金：湖北省科技厅资助项目 (2 0 0 2AA3 0 5B0 7)

摘　　要：目的　探讨环氧合酶 2 (cyclooxygenase 2 ,COX 2 )、c erbB 2、nm2 3 H 1、增殖细胞核抗原 (prolifer atingcellnuclearantigen ,PCNA)的表达与宫颈鳞癌预后的关系。 方法　应用免疫组化S P方法检测了3 0例正常宫颈和 52例宫颈鳞癌组织中COX 2、c erbB 2、nm 2 3 H1、PCNA的表达。结果　 (1)COX 2、c erbB 2表达与淋巴结转移无关 (P >0 .0 5) ,而PCNA表达与淋巴结转移呈正相关 (P <0 .0 5) ,nm 2 3 H1表达与淋巴结转移呈负相关 (P <0 .0 5) ;(2 )复发患者COX 2与PCNA表达阳性率明显高于未复发的患者 (P <0 .0 5) ,而nm2 3 H 1及c erbB 2表达与复发无关 (P >0 .0 5) ;(3 )COX 2、PCNA表达与预后呈负相关 ,而nm2 3 H1表达则与预后呈正相关 ,c erbB 2表达与生存无关。多因素分析表明淋巴结转移、COX 2、nm 2 3 H1是影响宫颈鳞癌预后的独立因素。结论　COX 2、nm2 3 H 1、PCNA是影响宫颈鳞癌预后的独立因素 ;COX 2 (+ ) /nm2 3 H 1(-)高度提示预后不良 ;c erbBObjective To study the association of expression of COX 2 ,c erbB 2 ,nm23 H1 , PCNA with the prognosis of cervical cancer.Methods Immunohistochemical assay was used to detect COX 2 , c erbB 2,nm23 H1 and PCNA in all specimens,including 52 cervical cancers and 30 normal cervices. Results (1) It was the expression of nm23 H1 and PCNA ,but not COX 2 and c erbB 2 ,that were related to lymph node metastasis( P < 0.05 ).The latter was positively correlated with lymph node metastasis while the former was negatively. (2) The expression of COX 2 and PCNA was more frequently detected in recurrent tumors( P < 0.05 ),while the expression of c erbB 2 and nm23 H1 were not related to recurrence( P > 0.05 ). (3) The expression of COX 2 and PCNA was negatively related to the prognosis in cervical carcinoma, with the expression of nm23 H1 being positively. The c erbB 2 expression had no relationship with survival .The multivariate Cox proportional hazard regression modal indicated that lymph node metastasis and the expression of COX 2 ,nm23 H1 have influence on prognosis. Conclusion COX 2,nm23 H1,and PCNA may be useful independent prognostic factors in squamous cell uterine cervical carcinoma. The patients with COX 2(+)/nm23 H1(-) are at higher risk of poor prognosis. c erbB 2 is of no prognostic significance in squamous cell uterine cervical carcinoma.

关 键 词：COX-2 C-ERBB-2 NM23-H1 PCNA 表达 宫颈鳞癌 预后 

分 类 号：R737.33[医药卫生—肿瘤]