老年人尸检中前列腺腺癌的发生情况  

Occurence of prostatic adinocarcinoma in senile autopsy cases

作　　者：张勇华[1] 张劲松[1] 杨丽[1] 林凤如[1] 马正中[1] 

机构地区：[1]北京医院病理科,100730

出　　处：《中华泌尿外科杂志》2004年第2期118-120,共3页Chinese Journal of Urology

摘　　要：目的　探讨老年人尸检前列腺腺癌的发生情况。　方法　采用光镜和免疫组化方法 ,观察 150例老年人 (62～ 10 2岁 )尸检前列腺标本的组织病理形态。　结果　 150例标本中原发前列腺腺癌 3 2例 (2 1.3 % ) ,其中前列腺临床癌 4例 (2 .7% ) ;前列腺潜伏癌 2 8例 (18.7% ) ,高分化 16例(57.1% ) ,中分化 10例 (3 5.7% ) ,低分化 2例 (7.1% )。潜伏癌中有高级别前列腺上皮内瘤 (HGPIN )者 9例 ,在高分化癌中占 3 1.2 % (5/ 16) ,中分化癌中占 40 .0 % (4/ 10 ) ,低分化癌中未发现 ;潜伏癌中发现有非典型腺瘤性增生 (AAH)者 2例。　结论　 60岁以上前列腺潜伏癌的发生率是欧美国家的1/ 2左右 ,绝大多数潜伏癌分化程度为高 中分化 。Objective To study the occurrence of pros ta tic adenocarcinoma in senile autopsy cases. Methods By m eans of light microscopy and in part by immunohistochemistry,the prostate gland of 150 senile autopsy cases (62～102 years) were scrutinized. Result s 32(21.3%) prostatic adenocarcinomas in 150 speicmens were found out 4(2.7%) cases were clinical prostatic adinocarcinoma;28(18.7%) were latent carc inoma,16( 57.1 %) well differentiated cancers,10(35.7%) moderate differentiate d and 2( 7.1 %) poorly differentiated.9 HGPINs in latent carcinomas were detec ted,rate of HGPIN detected in well and moderate differentiated cancers were 31.2 %(5/16) and 40.0%(4/10) respectively,no HGPIN in pooly differentiated cases;2 AA Hs were detected in latent carcinomas. Conclusions The i ncidence of latent prostatic adenocarcinoma in >60 years senile autopsy cases w as about half of that of western countries,most of latent carcinomas were well a nd moderate differentiated.HGPIN was closely associated with prostatic adenocar cinoma.

关 键 词：老年人 尸检 前列腺腺癌 免疫组化 组织病理形态 解剖 

分 类 号：R737.25[医药卫生—肿瘤]