拜糖苹治疗对急性脑梗死伴轻度高血糖患者的预后影响  

Prognostic influence on the cure of acarbose of patients with acute cerebral infarction and in association with hyperglycemia

作　　者：解旭东[1] 

机构地区：[1]河北保定中国人民解放军252医院神经内分泌科,071000

出　　处：《实用心脑肺血管病杂志》2004年第1期20-23,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的　观察拜糖苹治疗对急性脑梗死伴轻度高血糖患者的预后影响。　方法　 15 2例患者随机分入拜糖苹组 ,14 6例患者随机分入对照组。根据患者临床表现的不同 ,采用溶栓、活血化淤、脱水、营养神经、降纤、抗凝等方法综合治疗脑梗死 ,疗程 2周。拜糖苹组予拜糖苹 ,2 5mg～ 5 0mg,餐时口服或鼻饲 ,3次 日。对照组不予拜糖苹外 ,其余治疗同拜糖苹组。　结果　两组治疗前空腹、餐后血糖及神经功能缺损程度评分均无差异 (P >0 0 5 )。治疗后两组空腹血糖、餐后血糖差异有非常显著意义 (P <0 0 1)。神经功能缺损程度评分比较亦有显著差别 (P <0 0 1)。拜糖苹组治疗总有效率 86 8% ,明显高于对照组 76 7% (P <0 0 5 )。　结论　轻度血糖升高的急性脑梗死患者早期口服拜糖苹能明显改善神经功能缺损程度 ,提高生活质量 。Objective To observe prognostic influence on the cure of acarbose for patients with acute cerebraI infarction and in association with hyperglycemia Methods 298 patients with acute cerebral infarction and in association with hyperglycemia were randomly divided into two groups:152 patients received acarbose 25mg～50mg,p o,tid,for 2 weeks Other l46 patients only received routine treatment as the control Results No difference in fasting blood glucose,postcibal blood glucose and neurodysfunction score was found between the two groups before treatment(P>0 05),but there were significant differences after treatment(P<0 01 or P<0 05) There were significant differences in changes of neurodysfunction score in the two groups after treatment(P<0 01) The total effective rate in acarbose group(86 8%)was higher than that in the control group(76 7%,P<0 05) Conclusion Oral acarbose could significantly improve neurodysfunction score in patients with acute cerebral infarction and in association with hyperglycemia

关 键 词：拜糖苹 急性脑梗死 高血糖 预后 神经功能 迟发性神经元损伤 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R969[医药卫生—临床医学]