乳腺癌及淋巴结转移灶中上皮性钙粘素与α和β连接素的表达及意义  

Expressions of E-cadherin, and α-,β-catenin in Breast Cancers and Their Lymph-node Metastatic Tumors

作　　者：杨剑锋[1] 彭绍华[1] 陈森林[2] 谢平平[1] 

机构地区：[1]湖南师范大学医学院病理教研室,湖南长沙410006 [2]湖南省肿瘤医院病理科

出　　处：《中国医师杂志》2004年第2期170-172,共3页Journal of Chinese Physician

基　　金：湖南省卫生厅科研基金资助项目 (B2 0 0 3 - 1 1 7)

摘　　要：目的　探讨上皮性钙粘素 (E -cd)及α -、β -连接素 (cat)在乳腺癌组织及淋巴结转移灶中的表达及意义。 方法　免疫组化S -P法检测 60例乳腺癌 ( 3 1例有淋巴结转移 )及相应淋巴结转移灶中E -cd、α -、β -cat的表达。 结果　 60例乳腺癌组织中E -cd、α -、β -cat异常表达率分别为 5 1 7%、61 7%、70 %,E -cd的表达与乳腺癌淋巴结转移显著相关 ( P <0 0 0 5 ) ,α -、β -cat的表达与淋巴结转移无关。淋巴结转移灶中E -cd表达较相应原发灶明显增强 (P <0 0 0 5 ) ,淋巴结转移灶中α -、β -cat的表达与原发灶无显著差异。结论　原发灶E -cd的下调使癌细胞脱离原发灶 ,而转移灶内E -cd重新表达可能利于癌细胞黏附于远处器官 。Objective To investigate the protein expressions of E-cadherin and α-,β-catenin in breast cancers and their lymph-node metastatic tumors to evaluate their possible role in breast cancer invasion and metastasis. Methods High sensitive S-P immunohistochemical method was used to detect the protein expressions of E-cadherin and α-,β-catenin in 60 breast cancers(31cases with lymphatic metastasis) and their lymph-node metastatic tumors. Results The abnormal expression rates of the E-cadherin and α-,β-catenin were 51 7%, 61 7%, 70% respectively in the 60 cases of breast cancers. The expression of E-cadherin was significantly associated with lymphatic metastasis(P<0 05). However, there was no significant relationship between α-,β-catenin expression and lymph node metastasis. Expression of E-cadherin in metastatic lesion was significantly higher than that in primary tumor, while there was no significant difference in α-,β-catenin expressions between the primary tumor and metastatic lesion. Conclusions Down-regulation of E-cadherin may promote the tumor cells to release from the primary site, and re-expression of E-cadherin may be important for tumour cells to adhere in remote organs and to form metastatic tumors.

关 键 词：乳腺癌 淋巴结转移 上皮性钙粘素 α连接素 Β连接素 免疫组化S-P法 钙粘着蛋白 

分 类 号：R737.9[医药卫生—肿瘤]