造血干细胞移植前的全身大剂量放疗  

Systematic high dosage radiotherapy before transplantation of hematogenous stem cell

作　　者：杜向慧[1] 沈建平[2] 朱远[1] 狄小云[1] 陈秀勇[1] 黄河[3] 

机构地区：[1]浙江省肿瘤医院放疗科,310022 [2]浙江省中医院血液科,310006 [3]浙江大学附属第一医院血液科,310003

出　　处：《浙江临床医学》2004年第2期100-101,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 白血病、恶性淋巴瘤等恶性肿瘤造血干细胞移植前的全身大剂量放疗的探讨。方法 1997年10月～1999年10月对5例白血病、恶性淋巴瘤患者进行了造血干细胞移植前的全身大剂量放疗的预处理 ,采用钴60照射 ,剂量率5～5.5cGy/分 ,总剂量700～780cGy。结果 5例患者全身照射后均有轻到中度的恶心、呕吐、腮腺肿胀、口干等症状 ,3例有口腔溃疡、食欲减退 ,对症支持治疗后好转。5例中3例存活 ,1例移植后因Ⅳ度GVHD合并重症肝炎死亡 ,1例移植后5个月因复发死亡。无1例发生间质性肺炎。3例ABO血型不合者均转变为供髓者血型。结论 造血干细胞移植前的全身大剂量放疗是一种稳妥有效、值得重视的治疗方案。Objective To investigate the effect of high dose radiotherapy before transplantation of hematogenous stem cell in leukemia and malignant lymphoma.Methods From 10,1997 to 10,1999, five cases with leukemia, malignant lymphoma received the pretreatment of systematic high dosage radiotherapy before transplantation of hematogenous stem cell.Results Mild to moderate nausea, vomiting, parotid swollen and xerostomia appeared in five cases consistently after radiotherapy. 3 cases developed oral ulcer and anorexia but improved after allopathy and supportive therapy. 3 cases survived among 5 cases, and 1 case died of Ⅳdegree GVHD combined with severe hepatitis. 1case died of recurrence 5 months after transplantation. No pneumonia developed. Blood type of 3 cases whose blood type wasn't consistent with that of the donor's transformed into the donor's blood type.Conclusion High dosage radiotherapy before transplantation of hematogenous stem cell is an effective and considerable project for recipient.

关 键 词：造血干细胞移植 剂量 放疗 治疗 

分 类 号：R733[医药卫生—肿瘤]