代谢型谷氨酸受体与应激损伤  

Metabotropic glutamate receptors and stress response

作　　者：吴丽丽[1] 严灿[1] 徐志伟[1] 

机构地区：[1]广州中医药大学基础医学院,广州510405

出　　处：《中国药理学通报》2004年第2期125-128,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目;No 3 0 2 7164 9;3 0 0 0 0 2 17;国家中医药管理局资助课题 ;No 0 2 0 3JQ0 6

摘　　要：代谢型谷氨酸受体 (mGluRs)在应激性损伤中的作用日益受到重视 ,它可参与GC水平的调节 ,影响谷氨酸神经毒性作用和突触可塑性 (LTP、LTD)的诱导 ,由此表明mGluRs在应激性损伤中可能占有重要的地位。由于不同类型的mGluRs具有不同的作用 ,机制较为复杂 ,因此 。The function of metabotropic glutamate receptor(mGluRs) in stress response was increasingly gaining recognition. The mGluRs can regulate the level of glucocorticoid(GC), the neurotoxin of glutamate and synaptic plasticity (LTP,LTD). So it may play an important role in stress response. The function of distinct type of mGluRs is different. Their mechanisms in stress response are very complex. So it is very essential to study the function of mGluRs in stress. Furthermore we can explore a new type drug targeting at mGluRs to cure the stress damage.-

关 键 词：谷氨酸 代谢型谷氨酸受体 应激 

分 类 号：R-05[医药卫生] R338.1