水杉总黄酮对麻醉犬实验性心肌梗死的保护作用  

The protective effects of total flavones metasequosia on experimental myocardial infarction in anaesthetized dogs

作　　者：王芳[1] 余恩欣 刘惟莞[3] 屠治本[4] 

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]湖北省药品检验所药理室,武汉430064 [3]武汉大学医学院药理教研室,武汉430071 [4]中国科学院武汉植物研究所,武汉430074

出　　处：《中国药理学通报》2004年第2期163-165,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题;No 3 9970 0 85

摘　　要：目的　观察水杉总黄酮对麻醉犬急性心肌梗死的保护作用。方法　采用结扎犬冠状动脉左前降支的方法造成急性心肌梗死模型 ,十二指肠给药 ,测定犬冠脉循环及心肌耗氧量参数 ,心肌缺血程度和缺血范围 ,梗死面积 ,血清CK、LDH活性及FFA含量。结果　水杉总黄酮能降低冠脉阻力 ,增加冠脉流量 ,减少心肌耗氧量 ,减轻心肌缺血程度和缺血范围 ,缩小心肌梗死面积 ,降低血清CK、LDH活性及FFA含量。结论　水杉总黄酮能改善冠脉循环 ,减少心肌耗氧量 ,纠正心肌缺血时FFA代谢紊乱 ,对缺血心肌具有明显保护作用。AIM To study the protective effects of total flavones metasequosia(TFM) on experimental acute myocardial infarction (AMI) in anaesthetized dogs. METHODS The parameters of coronary circulation and myocardial oxygen consumption, the degree and range of myocardial ischemia, myocardial infarct size, the activity of serum CK,LDH and the content of FFA were determined by using the AMI model of ligature of LAD in the anaesthetized open-chest dogs. RESULTS In dogs treated with TFM(in a dosage of 25, 100 mg·kg -1 , id), the myocardial oxygen consumption, degree and range of myocardial ischemia, myocardial infarct size, the activity of serum CK,LDH and the content of FFA were decreased. At the same time, myocardial blood flow was increased and coronary vascular resistance decreased significantly. CONCLUSION TFM possesses a protective effect on myocardial ischemia by modifying dysfunction of FFA, decreasing myocardial oxygen consumption and increasing myocardial blood supply.-

关 键 词：水杉总黄酮 冠脉循环 心肌耗氧量 心肌代谢 心肌梗死 

分 类 号：R-332[医药卫生] R282.71