肝素单独应用及与红比霉素、阿霉素联合应用抑制结膜成纤维细胞增殖  

Effect of Haparin on Conjunctival Fibroblast Proliferation alone and in Combination with Daunorubicin or Doxorubicin

作　　者：徐岩[1] 杨国华[1] 宋晓虹[1] 陈克谦[1] 

机构地区：[1]河南省眼科研究所青光眼研究室,郑州450003

出　　处：《眼科研究》1992年第2期85-87,共3页Chinese Ophthalmic Research

摘　　要：我们测定了肝素单独应用及肝素分别与红比霉素、阿霉素联合应用在体外对兔结膜成纤维细胞的影响。证实肝素单独应用可明显抑制结膜成纤维细胞增殖,肝素的ID_(50)值为1.93mg/ml,肝素单独应用抑制成纤维细胞生长的效力比其与红比霉素或阿霉素联合应用的效力更大。肝素无明显副作用,有希望成为提高青光眼手术成功率的理想药物。We detected the effects of Heparin on conjunctival fibroblast proliferation aloneand in combination with Daunorubicin or Doxorubicin in vitro.Heparin is effective alonein specially controlling proliferation of rabbit conjunctival fibroblasts.Proliferation ofconjunetival fibroblasts was inhibited to 50% of control by 1.93mg/ml of Heparin.However,Heparin alone rather than in combination with Daunorubicin or Doxorubicin was mosteffective in inhibiting fibroblast proliferation.Heparin has not a direct toxicity on cells.It is hopeful to use heparin for preventing scar formation after glaucoma filtering surgery.

关 键 词：肝素 红比霉素 阿霉素 成纤维细胞 

分 类 号：R777.3[医药卫生—眼科]