牛精子非类固醇配子因子对实验性白内障大鼠代谢障碍的影响  

Effect of Nonsteroidal Gametic Factor(NSGF)Bull's Semen on the Metabolic Disturbance of Rats with Experimental Cataract

作　　者：于洪泉[1] 孙百鸣[1] 张明泉[1] 周秋丽[2] 白秀起 常淑芳[2] 李光秋[2] 杨春伟[2] 于涛[2] 

机构地区：[1]白求恩医科大学第一临床学院眼科,长春130021 [2]白求恩医科大学应用基础医学研究所

出　　处：《眼科研究》1992年第2期88-91,共4页Chinese Ophthalmic Research

摘　　要：本文应用d-半乳糖所致的大鼠模拟老年性白内障模型,观察了晶体自由基代谢及全身老化代谢改变。预期地证明,模拟老年性白内障大鼠存在明显的晶体自由基代谢紊乱和除晶体病变以外的其它组织细胞的退行性变化。从牛精子中部分提纯的水溶性非类固醇配子因子具有纠正白内障大鼠晶体自由基代谢紊乱,改善实验大鼠物质代谢和能量代谢水平的作用。We studied free radical metabolism in cataract lens and whole senile metabolicdisturbances induced by d-galatose in rats.The results showed that total amount of freeradicals in lens were increased apparently,SOD and GSH-Px activity decreased and LPOcontent rised significantly.In addition,the senescent degenerations were also observed.Itwas found that NSGF had apparent corrective effect on the metabolic disorder of freeradicals in cataract lens and normalized influence on senescent degeneration.

关 键 词：自由基代谢 NSGF 白内障 

分 类 号：R776.1[医药卫生—眼科]