褪黑素对心理应激大鼠胃黏膜SOD、MDA和胃黏膜损伤的影响  

Effects of melatonin on gastric mucosa lesions in rats with psychlological stress

作　　者：宋政军[1] 王友春[1] 画伟[1] 王粉荣[1] 林元喜[2] 

机构地区：[1]西安交通大学第一医院消化内科,陕西西安710061 [2]西安交通大学医学院病理生理学教研室,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2004年第1期69-72,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的　探讨褪黑素 (MT)对心理应激性胃黏膜损伤的保护作用及其机制。方法　 48只雄性SD大鼠随机分为对照组 (C组 )、规则光组 (R组 )、不规则光组 (I组 )和褪黑素组 (M组 )。检测大鼠胃黏膜损伤指数 (UI) ,胃黏膜超氧化物歧化酶 (SOD)活性、丙二醛 (MDA)含量及血清皮质醇浓度。结果　C组大鼠胃黏膜光整完好 ,肉眼未见糜烂及溃疡。R和I组UI均高于C组 (P <0 .0 5) ,M组UI低于I组 (P <0 .0 5)。R、I组胃黏膜SOD活性降低 ,I组降低更明显 (P <0 .0 5) ;R、I组胃黏膜MDA含量升高 ,I组升高明显 (P <0 .0 5) ,但M组SOD升高 ,MDA含量下降 (P <0 .0 5)。R、I组大鼠血清皮质醇升高 ,I组明显升高 (P <0 .0 5) ;而M组血清皮质醇较I组降低 (P <0 .0 5)。Objective To investigate the protective effects a nd mechanism of melatonin on the gastric mucosa lesions induced by psychlologica l stress in rats. Methods A total of 48 adult male rats wer e divided randomly into control group (C), regular stress group (R), irregular s tress group (I) and melatonin group (M). The gastric ulcer index (UI), level of serum cortisol, MDA and SOD activity were examined. Results The mean UI in M group was less than that of I and R groups. The level of seru m cortisol increased in R and I groups. It was decreased in M group significantl y ( P < 0.05 ). The activity of SOD in M group was higher than that of R and I groups ( P < 0 .05 ).The amount of MDA in R and I groups was higher than that of C group. It was decreased in M group ( P< 0.05 ). Conclusion Gastric mucosa lesion induced by psychological s tress can be significantly prevented by melatonin. The protection of melatonin a gainst gastric mucosal lesion by stress is due to antioxidant activity and the l owered level of serum cortisol.

关 键 词：褪黑素 心理应激 大鼠 胃黏膜 SOD MDA 胃黏膜损伤 自由基 丙二醛 超氧化物歧化酶 

分 类 号：R573[医药卫生—消化系统] R977.1[医药卫生—内科学]