胃癌及癌前病变组织中TGFα和cyclin E的表达及两者关联性分析  

Association of TGFα and Cyclin E Expression in Gastric Carcinoma and Precancerous Lesions

作　　者：梁卫江[1] 张万岱[1] 张亚历[1] 刘利民[1] 

机构地区：[1]第一军医大学南方医院全军消化内科研究所

出　　处：《癌症》2004年第3期259-263,共5页Chinese Journal of Cancer

摘　　要：背景与目的:研究发现,转化生长因子α(transforminggrowthfactoralpha,TGFα)或细胞周期素E(cyclinE)表达增高与肿瘤的发生、发展关系密切。但在胃癌前病变中的表达报道较少;两者表达的关联性分析未见报道。本研究旨在检测TGFα和cyclinE在慢性浅表性胃炎、胃癌前病变和胃癌组织中的表达情况,分析两者表达的关联性。方法:用免疫组织化学方法,检测TGFα和cyclinE在上述组织中的表达,分析两者表达在不同病理组织中的差异,以及两者表达的关联性。结果:在慢性浅表性胃炎、肠上皮化生、不典型增生及胃癌组织中,TGFα表达的阳性率分别为15.1%、53.6%、51.7%和61.7%,cyclinE分别为7.5%、28.6%、37.9%和42.6%,两者在肠上皮化生、不典型增生和胃癌的表达均高于在慢性浅表性胃炎的表达(均P<0.05)。在中-高分化腺癌和低分化腺癌,TGFα表达的阳性率分别为41.7%和81.0%,cyclinE分别为16.7%和57.1%,两者在低分化腺癌的表达均高于在中-高分化腺癌的表达(均P<0.05)。在胃慢性炎症组织(含癌前病变)以及在胃癌组织,TGFα和cyclinE的表达均存在显著的关联(分别为P<0.001和P=0.005)。结论:在慢性浅表性胃炎、癌前病变和胃癌组织中,TGFα和cyclinE的表达随病变严重程度以及胃癌恶性程度的增高而增高;BACKGROUND & OBJECTIVE: Previous studies have indicated that incr eased expression of TGFα and cyclin E are correlated with the oncogenesis and progress of cancer; however, their expression patterns in gastric precancerous l esions have been not clear yet. In addition, the association between expression of TGFα and cyclin E has not been reported. This study was designed to investi gate the expression of TGFα and cyclin E in chronic superficial gastritis (CSG ), gastric precancerous lesions, and gastric carcinoma (GCA), and analyze the as sociation of TGFα and cyclin E expression, and the relationship between their expression and different development stages of oncogenesis of GCA. METHODS: The expression of TGFα and cyclin E in CSG, intestinal metaphases (IM), atypical h yperplasia (AH), and GCA were examined using immunohistochemical staining. The a ssociation of TGFα and cyclin E expression was also statistically analyzed. RE SULTS:The expression rates of TGFα and cyclin E were 15.1%, 53.6%, 51.7%, 6 1.7%, and 7.5%, 28.6%, 37.9%, 42.6% in tissue samples of CSG, IM, AH and GC A, respectively. The positive expression rates of TGFα and cyclin E were high er in IM, AH, GCA than in CSG; the difference was significant (each P< 0.05). In addition, the positive expression rates of TGFα and cyclin E were higher in l ow differential adenocarcinoma (TGFα 81.0%, cyclin E 57.1%) than in mediate to high differential one (TGFα 41.7%, cyclin E 16.7%) (P< 0.05,for both TGF α and cyclin E). It is also revealed that the expression of TGFα and cyclin E were closely associated (P< 0.001 for the tissue of gastric chronic inflammat ion, and P=0.005 for gastric carcinoma, respectively). CONCLUSION: In the t issues of CSG, IM, AH, and GCA, the expression rates of TGFα and cyclin E are increased gradually with the severity of the pathological lesions and the malign ancy of GCA. In addition, the expression of TGFα and cyclin E were obviously a ssociated.

关 键 词：胃癌 癌前病变 TGFΑ CYCLINE 基因表达 肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]