细针抽吸、粗针切割和病灶染色切除三种方法诊断非扪及性乳腺疾病的比较  

Clinical Evaluation of Three Methods of Fine-Needle Aspiration, Large-Core N eedle Biopsy and Frozen Section Biopsy with Focus Staining for Non-palpable Breast Disease

作　　者：伍尧泮[1] 蔡培强[1] 张伟章[1] 唐军[2] 顾仰葵[1] 李立[1] 欧阳翼[1] 何洁华[3] 林浩皋[1] 

机构地区：[1]中山大学肿瘤防治中心影像介入中心,广东广州510060 [2]中山大学肿瘤防治中心胸科,广东广州510060 [3]中山大学肿瘤防治中心病理科,广东广州510060

出　　处：《癌症》2004年第3期346-349,共4页Chinese Journal of Cancer

摘　　要：背景与目的:提高乳腺癌疗效、延长患者生存期,关键在于早期诊断。而早期乳腺癌多为隐匿性,临床无法扪及,实验室检查也不能提供有效的检测方法,诊断困难。本研究旨在探寻有效的检查手段,以提高乳腺癌的早期诊断率。方法:选择钼靶照片发现有可疑恶性病变而临床未扪及肿块的患者24例,对每一病例进行计算机辅助钼靶立体定位,并分别行细针抽吸细胞学检查、粗针穿刺活检、病灶染色手术切除冰冻切片活检术,与术后病理对照。结果:本组细针抽吸细胞学检查、粗针穿刺活检和病灶染色手术切除冰冻切片检查的符合率分别为75%、92%和100%(P<0.05)。结论:计算机辅助钼靶立体定位病灶染色手术切除冰冻切片活检术是提高乳腺癌早期诊断率的理想诊断技术。BACKGROUND & OBJECTIVE: Early detection of breast cancer is cruc ial to improve the therapeutic effect and to increase the survival rate. However , it is difficult because breast cancer in early stage was usually occult, impal pable, and could not be detected by laboratory test. This study was designed to compare the effectiveness of three methods for diagnosis of non-palpable breast cancer. METHODS: Twenty-four patients with impalpable breast mass suggested by computer-aided stereotactic mammography were performed with three kinds of met hods, including fine-needle aspiration cytology (FNAC), large-core needle biop sy (LCNB), and frozen section biopsy (FSB) with focus staining. The results were compared with postoperative pathology. RESULTS: Compared with postoperative pat hology results, the diagnostic consistent rates of FNAC, LCNB and FSB with stain ing focus were 75%, 92%, and 100%, respectively (P< 0.05). CONCLUSION: Frozen section with focus staining guided by computer-aided stereotactic mammography was the effective diagnostic technique for non-palpable breast cancer.

关 键 词：细针抽吸 粗针切割 病灶染色 诊断 乳腺疾病 手术 肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]