翼状胬肉与角膜缘干细胞缺乏的病理研究  

A Pathological study of the limbal stem cells in the cervical pterygium

作　　者：刘新[1] 肖颖[2] 盛传家[2] 郭健[1] 念其钱[2] 陈勤[1] 

机构地区：[1]福州市第二医院眼科,350007 [2]福州市第二医院病理科,350007

出　　处：《福建医药杂志》2004年第1期3-4,共2页Fujian Medical Journal

基　　金：福州市科技发展基金(2001-108)

摘　　要：目的 研究翼状胬肉的发生与角膜缘干细胞缺乏的相关性。方法 通过对64例翼状胬肉手术病例切除的标本进行病理检查,在镜下观察翼状胬肉颈部组织的上皮细胞和正常角膜缘结膜上皮细胞以及干细胞的移行变化。结果 翼状胬肉头颈部表面上皮细胞层数减少,形态扁平,部分萎缩;翼状胬肉颈部与正常角膜缘球结膜的交界处上皮细胞排列层数逐渐移行减少,基底膜破坏,细胞排列不规则,缺乏基底的柱状细胞(角膜缘基底部柱状细胞包含角膜缘干细胞与短暂扩充细胞)。结论 角膜缘干细胞的缺乏和破坏可能是翼状胬肉发生的重要因素之一。Objective To study the relation between pterygium originating and limbal stem cell lacking. Methods The pathological changes of the limbal epithelium in the cervical pterygium were studied by pathological examining in 64 specimens. Results The epithelium cells in limbus was atrophy. The stem cells were consumed progressively between the cervical pterygium and limbus. Conclusion The stem cells lacking is one of the important cause in pterygium originting.

关 键 词：翼状胬肉 角膜缘干细胞缺乏 病理学 相关性 病因 

分 类 号：R777.33[医药卫生—眼科] R36[医药卫生—临床医学]