二阶导数差示脉冲极谱法的建立及在药物分析中的应用  

STUDIES ON SECONDARY DERIVATIVE DIFFERENTIAL PULSE POLAROGRAPHY AND ITS APPLICATIONS

作　　者：梁云爱 张天民[2] 

机构地区：[1]山东莒县药品检验所,莒县276500 [2]山东医科大学,济南250012

出　　处：《药学学报》1992年第2期157-160,共4页Acta Pharmaceutica Sinica

摘　　要：本文研究建立了二阶导数差示脉冲极谱法(SDPP),并将其运用于硫酸核糖霉毒、卡那霉素及其制剂的定量分析。方法简便、快速、灵敏,结果准确。 二阶导教差示脉冲极谱法(又名二阶导数高速脉冲极谱法)是在一阶导数差示脉冲极谱法(FDPP)基础上建立的。由FDPP的公式再进行求导得到本法的理论公式如下:Secondary derivative differential pulse polarography was developedand used for the quantitative analysis of ribostamycin sulfate, kanamycin and their prepa-rations. By using sodium hydroxide-potassium dihydrogen phosphate solution as thebase solution, ribostamycin sulfate and kanamycin showed good peaks at 0.105 V and- 0.37 V (vs Ag/AgCl) respectively. The linear relationship of ribostamycin sulfate andkanamycin between concentration and peak height was obtained in the concentrationrange of 1.8 ～10.8 ×10^(-4)mol/L and 3.1 ～18.6 ×10^(-4) mol/L and the determination limitwas 7.2 ×10^(-9) mol/L and 4. 6 ×10^(-8) mol/L respectively. This method is simple, rapidand sensitive. The result is accurate.

关 键 词：SDPP 药物分析 

分 类 号：R914.1[医药卫生—药物化学]