血小板激活因子对大鼠脑血管通透性的影响及药物的保护作用  

EFFECTS OF PLATELET ACTIVATING FACTOR ON THE CEREBROVASCULAR PERMEABILITY IN RATS AND THE PROTECTION BY DRUG.

作　　者：孙笃新[1] 黄彤舸[1] 曾国钱[1] 朱驹[1] 鞠佃文[1] 芮耀诚[1] 

机构地区：[1]第二军医大学药学院药理教研室,上海200433

出　　处：《药学学报》1992年第9期651-655,共5页Acta Pharmaceutica Sinica

摘　　要：颈内动脉注射血小板激活因子(PAF),再给伊文思蓝,可见脑实质染色程度加深,而颈内动脉只注射伊文思蓝,脑实质未见染色。而我们合成的新药SZ-1可剂量依赖性地抑制PAF诱导的脑实质伊文思蓝染色程度的加深。在体外培养的脑微血管平滑肌细胞上,PAF能显著刺激^(14)-花生四烯酸的释放,而SZ-1能剂量依赖性地抑制这种释放,提示PAF在脑内产生的损害除与其他因素相关外,还与其刺激花生四烯酸释放有密切关系,SZ-1对PAF引起的脑部损害有保护作用。The action of platelet activating factor in the rat brain was detected by Evans bluestaining after injection of PAF into the rat brain. The results show that PAF increased the Evans bluestaining of the brain, but no staining was observed without prior injection of PAF. Meanwhile, PAFwas shown to stimulate the release of (14)~C-arachidonic acid ((14)~C--AA) in the cerebral microvascularsmooth muscle cells (CMSMC). SZ-1, a new synthetic drug, dose-dependently inhibited the Evansblue staining of the rat brain and the PAF induced (14)~C-AA release in CMSMC. These results indicate that the action of PAF in the rat brain might be related to the stimulation of AA release. SZ-1 may an-tagonize the PAF receptor and protect the brain from PAF induced damage.

关 键 词：脑血管疾病 花生四烯酸 PAF 

分 类 号：R743.05[医药卫生—神经病学与精神病学]