脑梗死急性期血浆炎性细胞因子及刺五加治疗的临床研究  

The Clinical Research on Measuring the Inflammation Cytokmes and Ciwujia Treatment in the Acute Cerebral Infarction

作　　者：杜贤兰[1] 胡承志[1] 刘建华[1] 朱丽[2] 秦绪光[2] 贾长海[1] 向瑾[1] 钟恺立[1] 钟兴美[1] 

机构地区：[1]成都市第一人民医院综合内科,成都610016 [2]清华大学附属医院心脏中心,北京100016

出　　处：《中国医药导刊》2004年第1期25-27,共3页Chinese Journal of Medicinal Guide

基　　金：成都市卫生局青年基金资助项目

摘　　要：目的:探讨急性脑梗死患者血浆炎性细胞因子包括血管内皮素(ET),白细胞介素-8(IL-8),肿瘤坏死因子(TNF-α)水平,用刺五加注射液治疗前后的变化,对神经缺损评分的影响。方法:将60例入选的脑梗死急性期患者随即分为刺五加组和对照组,用刺五加注射液60ml静脉滴注,每日一次,连续14天。观察其用药前后血液炎性细胞因子浓度变化及神经缺损评分改变。结果:ET、IL-8、FNF-α及神经缺损评分两组比较P<0.01,具有显著性差异。结论:血浆炎性细胞因子参与了脑梗死缺血损害的全过程,可作为检测病情发生发展的重要指标。刺五加注射液可显著降低炎性细胞因子的水平,可能是通过机体内部神经-内分泌-免疫调节网络起作用,从而降低神经缺损评分,改善疾病愈后。Objective: To explore the level of inflammation cytokines in the acute cerebral infarction including ET, IL-8, TNF-a, and the change after the treatment of Chinese medicine ciwujia injection, and the influence of nerve deficiency evaluate. Methods: Random divided 60 selected acute cerebral infarction patients into ciwujia group and control group, use ciwujia injection 60 ml iv. gtt, qd continue 14 days. Investigate changes of inflammation cytokines in blood and nerve deficiency evaluate in plasma before and after treatment. Results: Result Compare ET、IL-8、TNT-α and nerve deficiency evaluate between two groups P<0.01, chiwujia group shows more distinct effect. Conclusion: Inflammation cytokines are related to the whole process of cerebral infarction ischemia injure, it can use as important marker for the cause and development of cerebral infarction. Ciwuji injection can reduce the level of inflammation cytokines, maybe it effect with the never-liquid-immunity, reduce nerve deficiency evaluate, improve healing.

关 键 词：脑梗死 急性期 血浆 炎性细胞因子 治疗 刺五加注射液 神经缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]