多发性硬化患者事件相关电位的检测及其情感障碍的评价  

Determination of event-related potentials and evaluation of emotional disorder in patients with multiple sclerosis

作　　者：许虹[1] 李美山[1] 徐飞[2] 李方[2] 

机构地区：[1]昆明医学院第一附属医院神经内科,云南昆明650032 [2]昆明医学院第一附属医院精神科,云南昆明650032

出　　处：《临床神经电生理学杂志》2004年第1期11-13,共3页Journal of Clinical Electroneurophysiology

基　　金：云南省教育厅科研基金资助项目(编号 0 112 42 3 );云南省卫生厅科研基金资助项目(编号 :2 0 0 10 0 60 )

摘　　要：目的 :评价多发性硬化 (MS)患者的认知损害以及情感障碍。方法 :对 4 0例MS患者进行事件相关电位 (ERP)的检测并与汉密尔顿焦虑和抑郁量表 (HAMA和HAMD)的评分进行比较。结果 :部分MS患者出现N2和P3波潜伏期延长以及HAMA和HAMD评分的增高。结论Objective:To evaluate the cognitive impairment and emotional disorders of patients with multiple sclerosis (MS).Methods:The event related potentials (ERP) were determined in 40 patients with MS and the score by Hamilton Anxiety and Depression Scale (HAMA and HAMD) was performed.Results:The latency prolongation of N2 and P3 waves and score increase of HAMA and HAMD were found in some patients with MS.Conclusions:MS patients might have cognitive impairment and anxiety or depression state.

关 键 词：多发性硬化 事件相关电位 情感障碍 认知功能损害 焦虑 抑郁 

分 类 号：R744.51[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]