宫颈癌PCNA、ICAM-1的表达及其意义  

EXPRESSION OF PCNA AND ICAM-1 IN CERVICAL CARCINOMA AND ITS SIGNIFICANCE

作　　者：吴莉[1] 谢东[2] 任崇敏[1] 孙渝[1] 钟愉[1] 

机构地区：[1]贵阳医学院附属医院,贵阳550004 [2]解放军第44医院

出　　处：《解放军医学杂志》2003年第7期640-641,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：目的　探讨宫颈癌组织中PCNA、ICAM 1表达的意义。方法　治疗前取活检并应用免疫组化方法检测初治的 43例宫颈癌组织中PCNA及ICAM 1的表达。结果　治疗后按WHO疗效评价标准 ,完全缓解 (CR) +部分缓解(PR)患者的染色组织切片中PCNA表达 3 8 2 %的患者为阴性 (— ) ,3 1 3 %的患者为强阳性 ( ) ;无变化 (NC) +病变进展 (PD)患者的染色组织切片中PCNA表达为阴性(— )的患者为 0 ,77 8%的患者为强阳性 ( ) ,差异有显著性意义 (P <0 0 5 )。PCNA与ICAM 1共同表达在宫颈癌的临床分期Ⅱ期与Ⅲ+Ⅳ期中的表达率分别为 2 5 0 %、78 9% ,差异有显著性意义 (P <0 0 1)。结论　PCNA的单一阳性与近期疗效呈负相关 ;PCNA、ICAM 1共同表达在宫颈癌的临床分期中有显著差异 。Objective To explore the significance of PCNA and ICAM-1 expression in cervical carcinoma. Method Pre-treatment biopsy was conducted and immunohistochemical method was used after treatment to determine the expression of PCNA and ICAM-1 in the tissues of 43 patients with cervical carcinoma. Results The post-treatment evaluation was based on WHO standard. The section staining showed that 38.2% of the CR and PR patients was negative(―) and 31.3% was positive plus() in terms of PCNA expression while none of the NC and PD patients was found negative(―)and 77.8% was found positive plus(). The expression difference was significant(P<0.05). The common expression rates of PCNA and ICAM-1 were 25.0% and 78.9% respectively at phase II and phase III+IV of cervical carcinoma and the difference was significant. Conclusion A negative correlation was found between the positive rate of PCNA and short-term therapeutic effect. A significant difference was also shown at different clinical phases of cervical carcinoma in terms of the common expression of PCNA and ICAM-1, which can be taken as an useful indicator for the prognosis of cervical carcinoma.

关 键 词：宫颈肿瘤 增殖细胞核抗原 胞间粘附分子 

分 类 号：R737.33[医药卫生—肿瘤]