E-钙黏附素和α-连接素在乳腺癌组织中的表达及其临床意义  

Expression of E-Cad and α-Cat and its Clinical Significance in Breast Cancer

作　　者：张青松[1] 周宝臣[1] 赵光明[2] 张素华[2] 张文杰[2] 

机构地区：[1]华北煤炭医学院附属开滦医院,063000 [2]华北煤炭医学院附属医院,063000

出　　处：《实用癌症杂志》2004年第1期50-52,61,共4页The Practical Journal of Cancer

摘　　要：目的　探讨E 钙黏附素 (E Cad)和α 连接素 (α Cat)在乳腺癌组织中的表达及其临床意义。方法　应用免疫组织化学方法 ,检测 77例乳腺癌、15例乳腺增生和 15例乳腺纤维腺瘤组织中E Cad、α Cat表达水平。结果　E Cad及α Cat在乳腺癌组织中的阳性率分别为 5 5 .8% ( 4 3 /77)及 3 9.0 % ( 3 0 /77) ,均明显低于乳腺增生和乳腺纤维腺瘤组织 (P <0 .0 5 ) ;E Cad与乳腺癌腋窝淋巴结转移、远处转移有关 (P <0 .0 5 ) ,α Cat与乳腺癌腋窝淋巴结转移有关 (P <0 .0 5 )。结论　E Cad、α Cat在乳腺癌浸润和转移中可能起重要作用 。Objective To study the expression of E-Cad and α-Cat and its clinical significance in breast cancer.Methods Immunohistochemical method was used to investigate the expression of E-Cad and α-Cat in 77 cases of breast cancer,15 cases of breast fibroadenoma and 15 cases of breast proliferation.Results The positive rates of E-Cad and α-Cat were 55.8%(43/77) and 39.0%(30/77)in breast cancer,which were significantly lower than those in breast fibroadenoma and breast proliferation(P<0.05).The expression of E-Cad significantly related with lymph node status and distant metastasis(P<0.05).The expression of α-Cat showed a significant relationship with axillary lymph node status(P<0.05).Conclusion The expression of E-Cad and α-Cat may play an important role in infiltration and metastasis of breast cancer.It has a significance for the prognosis of the patients with breast cancer.

关 键 词：E—钙黏附素 Q—连接素 乳腺癌 表达 癌组织 预后 

分 类 号：R737.9[医药卫生—肿瘤]