中国人遗传性非息肉病性结直肠癌相关肿瘤谱及累计发病风险  

Cancer spectum and cumulative lifetime risk for hereditary nonpolyposis colorectal cancer in Chinese

作　　者：金黑鹰[1] 颜宏利[2] 马修强[3] 贺艳[2] 丁义江[4] 孟荣贵[1] 阎于悌[5] 崔龙[1] 孙树汉[2] 

机构地区：[1]第二军医大学长海医院肛肠外科,上海200433 [2]第二军医大学基础医学部医学遗传学教研室 [3]第二军医大学卫生勤务学系卫生统计学教研室 [4]南京市中医院肛肠外科,南京210001 [5]甘肃省人民医院肛肠科,兰州730000

出　　处：《第二军医大学学报》2004年第2期133-135,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金 ( 3 9970 82 3 ;3 0 170 92 7)

摘　　要：目的 :探讨中国人遗传性非息肉病性结直肠癌 (HNPCC)相关肿瘤谱和累计发病风险 ,为制定 HNPCC诊治方案提供依据。方法 :随访 31个 HNPCC家系中 1 6 7例肿瘤患者 ,以 Kaplan- Meier生存曲线法估计各种肿瘤发生比例和累计发病风险。 结果 :1 6 7例 HNPCC相关肿瘤患者的首发肿瘤中 ,结直肠癌 1 35例 (80 .8% ) ,胃癌 1 0例 (6 .0 % ) ,子宫内膜癌 8例(4 .8% ) ,卵巢癌 3例 (1 .8% ) ,膀胱癌、乳腺癌、肺癌和脑胶质瘤各 2例 (分别占 1 .2 % ) ,肝癌、胰腺癌和胆囊癌各 1例 (分别占0 .6 % )。70岁时 ,大肠癌发生累计发病风险为 93.3% ,肠外肿瘤发生累计发病风险为 5 6 .1 %。 结论 :中国人 HNPCC肿瘤谱中 ,胃癌发生率较高 ;4 0～ 6 0岁大肠癌发生风险最大 ,5Objective:To study the cancer spectum and cumulative lifetime risk for hereditary nonpolyposis colorectal cancer(HNPCC) in Chinese. Methods:Totally 167 patients with HNPCC were followed up and the cumulative lifetime risk were estimated by Kaplan Meier life curves. Results:Among 167 HNPCC associated cancer patients, 135(80.8%) patients had colorectal cancer, 10(6.0%) had gastric cancer, 8(4.8%) had endometrium cancer, and 3(1.8%) had ovarian cancer. At the age of 70,the cumulative lifetime risk of colorectal cancer was 93.3% and extracolonic cancer was 56.1%.Conclusion: In Chinese HNPCC families, gastric cancer ranks the second following colorectal cancer. Cumulative lifetime risk of colorectal cancer increases greatly between the age of 40 to 60 and the cumulative lifetime risk of extracolonic cancer increases sharply after 50.

关 键 词：中国人 遗传性非息肉病性结直肠癌 肿瘤谱 累计发病风险 家系 

分 类 号：R735[医药卫生—肿瘤] R394[医药卫生—临床医学]