N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis  

作　　者：SongQingWANG OmarA.IBRAHIMI PanLI KangZHAO 

机构地区：[1]CollegeofPharmaceuticalsandBiotechnology,TianjinUniversity,Tianjin300072 [2]DepartmentofChemistry,NewYorkUniversity,NewYork,NY10003,USA

出　　处：《Chinese Chemical Letters》2004年第1期1-4,共4页中国化学快报（英文版）

摘　　要：Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2' mechanism to give the desired N-alkoxyl pyrrolidines.Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2' mechanism to give the desired N-alkoxyl pyrrolidines.

关 键 词：SN' reaction PYRROLIDINES OXIME hydroxylamine. 

分 类 号：O626.13[理学—有机化学]