Two cases of extranodal follicular dendritic cell sarcoma  

作　　者：王坚 孔蕴毅 陆洪芬 许越香 

机构地区：[1]Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032

出　　处：《Chinese Medical Journal》2003年第5期794-797,共4页中华医学杂志（英文版）

摘　　要：Follicular dendritic cell (FDC) is an essential component of the nonlymphoid, nonphagocytic immunoaccessory reticulum cells of the peripheral lymphoid tissue(1). FDCs are confined largely to the primary and secondary B-cell follicles, where they form a tight interlacing meshwork. They play a role in the capture and presentation of antigens, generation and regulation of immune complexes. FDCs can be recognized morphologically by their indistinct cellular borders, pale eosinophilic cytoplasm, round-to-ovoid nuclei with delicate nuclear membranes and clear-to-vesicular chromatin with inconspicuous or small nucleoli. FDCs are best identified through immunostaining using CD21, CD35, R4/23, KiM4, KiM4p and Ki-FDC1p. A proliferation of FDCs may be seen in a variety of lesions, including reactive follicular. hyperplasia, Castleman's disease, follicular lymphoma, mantle cell lymphoma, angioimmunoblastic T-cell lymphoma and nodular lymphocyte predominant Hodgkin's lymphoma. Previous studies(2-5) showed that follicular dendritic cell sarcoma (FDCS) affected predominantly the lymph nodes, with occasional extranodal involvement. As the tumor consists mainly ovoid-to-spindle cells, it is not uncommon to misdiagnose the lesion as a wide variety of other spindle cell sarcomas. This study focused on characterizing the histologic features of extranodal FDCS to promote the recognition of this rare entity for both clinicians and pathologists.Follicular dendritic cell (FDC) is an essential component of the nonlymphoid, nonphagocytic immunoaccessory reticulum cells of the peripheral lymphoid tissue(1). FDCs are confined largely to the primary and secondary B-cell follicles, where they form a tight interlacing meshwork. They play a role in the capture and presentation of antigens, generation and regulation of immune complexes. FDCs can be recognized morphologically by their indistinct cellular borders, pale eosinophilic cytoplasm, round-to-ovoid nuclei with delicate nuclear membranes and clear-to-vesicular chromatin with inconspicuous or small nucleoli. FDCs are best identified through immunostaining using CD21, CD35, R4/23, KiM4, KiM4p and Ki-FDC1p. A proliferation of FDCs may be seen in a variety of lesions, including reactive follicular. hyperplasia, Castleman's disease, follicular lymphoma, mantle cell lymphoma, angioimmunoblastic T-cell lymphoma and nodular lymphocyte predominant Hodgkin's lymphoma. Previous studies(2-5) showed that follicular dendritic cell sarcoma (FDCS) affected predominantly the lymph nodes, with occasional extranodal involvement. As the tumor consists mainly ovoid-to-spindle cells, it is not uncommon to misdiagnose the lesion as a wide variety of other spindle cell sarcomas. This study focused on characterizing the histologic features of extranodal FDCS to promote the recognition of this rare entity for both clinicians and pathologists.

关 键 词：follicular dendritic cell sarcoma  · small bowel mesentery · pharynx 

分 类 号：R733.1[医药卫生—肿瘤]