碱性成纤维细胞生长因子对阻生齿干槽症发生的预防实验  

Protection of basic fibroblast growth factor on dry socket after mandibular impacted tooth extraction

作　　者：温宁[1] 韩亮[1] 陆怀秀[2] 毛天球[3] 王忠义[3] 刘宏臣[1] 

机构地区：[1]解放军总医院口腔科,北京市100853 [2]解放军海军总医院口腔科,北京市100036 [3]解放军第四军医大学口腔医学院颌面外科,陕西省西安市710032

出　　处：《中国临床康复》2004年第5期858-859,共2页Chinese Journal of Clinical Rehabilitation

基　　金：陕西省自然科学基金(99SM35)~~

摘　　要：目的:研究下颌阻生齿拔除后应用碱性成纤维细胞生长因子(bFGF)对拔牙后干槽症发病的预防作用。方法:采用随机数字表法分组,双盲试验的临床流行病学方法,观察拔牙后即刻应用bFGF组与应用安慰剂组干槽症的发病率比较。结果:应用bFGF组拔牙后干槽症的发病率1.61%,明显少于对照组发病率13.11%(P<0.05,χ2=5.998)。结论:下颌阻生齿拔牙后局部应用bFGF对干槽症的发病有预防作用。AIM:To investigate the protective effect of basic fibroblast growth factor(bFGF) on dry socket after mandibular impacted tooth extraction. METHODS:The method of random digit dialing was adopted to divide groups.The dry socket incidence in the group which immediately applied bFGF(trial group) after tooth extraction and the group which applied placebo(control group) were observed by using double blinded test of clinical epidemiology.Clinical check were taken after tooth extraction 1 week to evaluate the preventive effect. RESULTS: The dry socket incidence of the trial group was 1.61%,which was significantly lower than that of the control group(13.11%)(P< 0.05,χ2=5.998). CONCLUSION:The administration of bFGF following tooth extraction has a preventing effect on dry socket after mandibular impaction tooth extraction.

关 键 词：碱性成纤维细胞生长因子 阻生齿 干槽症 预防 实验 拔牙 

分 类 号：R782.1[医药卫生—口腔医学]