健胃愈疡颗粒剂对胃溃疡患者胃黏膜表皮生长因子受体表达的影响  

Effect of Jianwei Yuyang Granules on expression of epidermal growth factor receptor in gastric mucosa of gastric ulcer patients

作　　者：张炜宁 张烨[2] 李家邦[3] 

机构地区：[1]深圳市福田区中医院内科,广东深圳518034 [2]湖南中医学院第一附属医院妇产科,湖南长沙410007 [3]中南大学湘雅医院中西医结合研究所,湖南长沙410008

出　　处：《中西医结合学报》2004年第1期24-26,共3页Journal of Chinese Integrative Medicine

基　　金：20 0 1年度湖南省自然科学基金资助项目 (No .2 0 0 10 42 3 5 )

摘　　要：目的 :观察健胃愈疡颗粒剂对胃溃疡患者胃黏膜表皮生长因子受体 (epidermalgrowthfactorreceptor ,EGFR)表达的影响。方法 :6 0例胃溃疡患者随机分为治疗组和对照组 (各 30例 ) ,分别给予健胃愈疡颗粒剂和西药常规治疗 ,治疗前后采用免疫组织化学和逆转录聚合酶链反应法检测其胃黏膜EGFR表达水平。另设无消化性溃疡者 10例作为阴性对照组。结果 :无胃黏膜损伤病变者胃黏膜几乎无EGFR及其mRNA表达 ;胃溃疡患者溃疡区边缘可见少量表达。经健胃愈疡颗粒剂及西药治疗者 ,EGFR及其mRNA呈现上增性表达。结论 :健胃愈疡颗粒剂通过增加胃黏膜EGFR的表达进而提高溃疡愈合质量 。Objective:To observe the effect of Jianwei Yuyang Granules on the expression of epidermal growth factor receptor (EGFR) in the gastric mucosa of gastric ulcer patients. Methods:Sixty gastric ulcer patients (final diagnosis by gastroscope) were randomly divided into Jianwei Yuyang Granules treated group (JWYY group, n=30) and western medicine treated group (control group, n=30). Ten patients without gastric mucosa lesion were treated as normal control group. The expression of EGFR in the mucosa was tested by immunohistochemistry and RT-PCR. Results:Expression of EGFR and EGFR mRNA was not observed in patients without gastric mucosa lesion, and slight expression was observed in the edge of ulcer region of the gastric ulcer patients. The expression of EGFR and EGFR mRNA was increased in JWYY group and control group. Conclusion:Jianwei Yuyang Granules enhances the expression of EGFR in the mucosa of gastric ulcer patients to prevent peptic ulcer recurrence.

关 键 词：健胃愈疡颗粒剂 胃溃疡 胃黏膜 表皮生长因子受体 EGFR 治疗 消化性溃疡 PU 

分 类 号：R259[医药卫生—中西医结合]