眼角膜在冻干过程中的传热传质模型  

Heat and Mass Transfer Mathematical Analysis for Cornea during Vacuum Freeze-drying

作　　者：邹惠芬[1] 徐成海[2] 苏永升[1] 周邵萍[1] 

机构地区：[1]华东理工大学机械工程学院,上海200237 [2]东北大学机械工程学院,沈阳110004

出　　处：《华东理工大学学报（自然科学版）》2004年第1期91-95,共5页Journal of East China University of Science and Technology

基　　金：国家自然科学基金资助项目(59876008)

摘　　要：通过对角膜干燥过程的理论分析,建立了能真实描述角膜干燥过程传热传质的数学模型。采用ANSYS有限元计算软件对角膜的冻干过程进行模拟计算,得出如下结果:冻干室内温度约-10℃,压强维持在50Pa左右时,角膜双面冻干所需时间为170min。采用移动网格来追踪升华界面上各节点的参数值,提高了本模型的计算精度,计算结果直观可靠,物理意义明确。Theory analysis of corneal freeze-drying, mathematical model of describing heat and mass transfer during vacuum freeze-drying of cornea was established. The analogy computation for the freeze-drying of cornea was made by using ANSYS finite-element computational software. When pressure of the freeze-drying box is about 50 Pa and temperature is about -10℃, the time of double-side drying is 170 min. In this paper, a moving-grid finite-element method was used. The sublimation interface was tracked continuously. The finite-element mesh is moved continuously such that the interface position always coincides with an element node. Computational precision is guaranteed.

关 键 词：眼角膜 真空冷冻干燥 传热传质模型 有限元计算 

分 类 号：R322.91[医药卫生—人体解剖和组织胚胎学] TB79[医药卫生—基础医学]