硒化亚麻酸的抗癌作用研究  

STUDIES ON THE ANTITUMOR EFFECT OF LINOLENIC ACID CONTAINING SELENIUM

作　　者：薛少安 吕登仕 杨志学 李宝林[1] 陶静仪[4] 

机构地区：[1]陕西师范大学化学系,西安710062 [2]榆林地区中医院 [3]陕西省肿瘤防治研究办公室 [4]第四军医大学药理教研室

出　　处：《营养学报》1992年第4期363-367,共5页Acta Nutrimenta Sinica

基　　金：卫生部科学研究基金

摘　　要：用作者首次合成的硒化亚麻酸进行动物体内外抗癌活性实验,结果表明:小鼠腹腔注射200mg·kg^(-1)·d^(-1)硒化亚麻酸乳剂(82)时,小鼠S_(180)实体瘤的抑制率为42.6％(P<0.01),对荷ARS腹水瘤小鼠的治愈率达75％,生命延长率达132％(P<0.01);在体外250μg/ml的浓度下,硒化亚麻酸对小鼠S_(180)腹水型瘤细胞的杀伤作用也明显高于亚麻酸。这些结果提示,硒化亚麻酸具有较强的抗癌作用。Linolenic acid containing selenium was synthesized and brought into emul- sion(82). Its aatitumor effects were tested in vitro and in vivo. As a result, when 82 was injected peritoneally into mice(200mg·kg-1·d-1), its inhibitory rate on mouse S180 was 42.6%(P<0.01); its cure rate on the mice bearing ARS ascites tumor reached 75%, and its survival prolongation on the mice bearing ARS ascites tumor reached 132%(P<0.01). The in vitro antitumor effect of linolenic acid containing selenium is also much stronger than that of linolenic acid at the concentration of 250μg/ml. These results showed that linolenic acid containing selenium bore obvious antitumor activity.

关 键 词：亚麻酸 肿瘤抑制 硒 抗癌药 

分 类 号：R979.1[医药卫生—药品]