3-甲基-4-苯基-1,2,4-三唑-5-酮合成的研究  

A study on the synthesis of 3-methyl-4-phenyl-1,2,4-triazol-5-one

作　　者：刘毅锋[1] 张娟[1] 李华[1] 张雄[1] 王翠玲[1] 杨孟林[1] 

机构地区：[1]西北大学应用化学研究所,陕西西安710069

出　　处：《西北大学学报（自然科学版）》2004年第1期56-59,共4页Journal of Northwest University（Natural Science Edition）

基　　金：陕西省教育厅重点资助项目(97JZK12)

摘　　要：目的　研究3 甲基 4 苯基 1,2,4 三唑 5 酮合成的新方法。方法　以三氯氧磷为缩合剂,在110℃反应3h,用碱中和后,分离中间产物,再进行环化反应。结果　两步反应总产率74.3%,比相关文献报道值,高出30%,并对目标物质进行了分析鉴定和表征。结论　反应条件温和,产率高,具有较好的应用前景。Aim3-methyl-4-phenyl-1,2,4-triazol-5-one was prepared by the reaction of N-phenyl acetamide with ethyl hydrozino-formate .Methods At 110℃ for three hours in the presence of POCl_3 , following neutralization and cyclization reaction.ResultsGiving a 74.3% yield(in total) of title compound which are 30% more than literature report . The title compound was characterized by HNMR, IR and elementary analysis.ConclusionThe method of preparation of 1,2,4-triazolone derivative is more available with mild reaction condition and good yield.

关 键 词：1 2 4-三唑-5-酮 肼基甲酸酯 乙酰苯胺 合成 杂环 

分 类 号：TQ252.6[化学工程—有机化工]