人肺癌组织多药耐药基因的探讨  

Analysis of multi-drug resistance genes in human lung cancer

作　　者：孙云晖[1] 李冬梅[2] 邢宇彤[1] 鲍文华[1] 穆海玉[1] 闫红娥[1] 

机构地区：[1]佳木斯大学附属第一医院,黑龙江佳木斯154003 [2]沈阳医学院附属二院,辽宁沈阳110002

出　　处：《黑龙江医药科学》2004年第1期7-8,共2页Heilongjiang Medicine and Pharmacy

摘　　要：本文采用 RT- PCR方法检测了 38例 NSCL C肿瘤组织 ,10例良性瘤样病变和 35例病灶旁正常肺组织中 mdr1基因的表达水平。结果表明 ,肺癌组织中 mdr1m RNA过度表达 ,因此推测 mObjective:To study drug resistance in human lung tumors with the reverse transcription polymerase chain reaction (RT-PCR) ,the expression leve1 of mdr1 gene was evaluated in 38 NSCLC tumor samples, 10 benign phymatoid lesion and 35 adjacent normal lung tissue samples. Results: The expression of mdr1 gene was higher in lung cancer. Conclusion:The expression of mdr1 gene is considered to be an important mechanism involved in drug resistance in human lung tumors.

关 键 词：肺癌 多药耐药性 MDR1基因 

分 类 号：R743.2[医药卫生—神经病学与精神病学]