冷冻联合无水乙醇瘤内注射治疗无法手术切除的肝癌  

Cryotherapy combining with ethanol injection therapy in the treatment of irresec table hepatic cancer

作　　者：朱伟良[1] 张健[1] 张积仁[1] 汪森明[1] 赵燕[1] 

机构地区：[1]第一军医大学附属珠江医院肿瘤中心,广东广州510282

出　　处：《中国癌症杂志》2004年第1期52-54,58,共4页China Oncology

摘　　要：目的 :采用经皮局部冷冻治疗 (percutaneouslocalcryotherapy ,PLCT )和经皮瘤内无水乙醇注射治疗(percutaneousethanolinjectiontherapy ,PEIT)失去手术机会的肝癌 ,观察其疗效和安全性。 方法 :43例肝癌患者分为 3组 ,14例患者 2 9个病灶施行PLCT ,16例患者 2 3个病灶施行PEIT ,13例患者 2 3个病灶施行PLCT联合PEIT治疗。结果 :单纯PLCT治疗的肿瘤大小 50 %以上缩小率为 51 7% (15/ 2 9) ;单纯PEIT治疗的肿瘤 50 %以上缩小率为 43 5% (10 / 2 3 ) ;PLCT联合PEIT治疗的肿瘤 50 %以上缩小率为 78 3 % (18/ 2 3 )。单纯PLCT治疗后一年生存率为 64 3 % (9/ 14 ) ,单纯PEIT治疗后为 43 8% (7/ 16) ,PLCT联合PEIT治疗后为 84 6% (11/ 13 )。各组患者AFP水平治疗后有不同程度下降。结论 :PLCT联合PEIT治疗其效果优于单纯PLCT或单纯的PEIT治疗。Purpose:To observe the effect and safety of c om bination therapy with Percutaneous Local Cryotherapy(PLCT)and Percutaneous Etha nol Injection Therapy( PEIT)in patients with irresectable hepatic cancer Methods:43 patients with irresectable hepatic carcinoma were enrolled 29 tumors of 14 patients were treated by PLCT,23 tumors of 16 patients were treated by PEIT,and 23 tumors of 13 patients were treated by combination therapy Results :The tumor size decreased by more than 50% 1 month later in 51 7%(15/29 )of tumors treated by PLCT alone, in 43 5%(10/23)of tumors treated by PEIT alone, 78 3%(18/23)tumors treated by combination therapy The 1-year surv ival rates were 64 3%(9/14) in PLCT group?43 8%(7/16) in PEIT group?8 4 6%(11/13)in combination therapy group The blood levels of AFP decreased by various extents Conclusions:Combination therapy with PLCT a nd PEIT is more effective than PLCT or PEIT alone

关 键 词：肝肿瘤 冷冻治疗 乙醇 联合治疗 

分 类 号：R735.7[医药卫生—肿瘤]