New animal model of emotional stress:Behavioral,neuroendocrine and immunological consequences  

作　　者：LINWenjuan WANGWeiwen SHAOFeng 

机构地区：[1]Brain-BehaviorResearchCenter,InstituteofPsychology,ChineseAcademyofSciences,Beijing100101,China [2]DepartmentofPsychology,PekingUniversity,Beijing1000871,China [3]KeyLaboratoryofMentalHealth,ChineseAcademyo

出　　处：《Chinese Science Bulletin》2003年第15期1565-1568,共4页

基　　金：supported by the National Natural Science Foundation of China(Grant No.39830130);the Knowledge Innovation of the Chinese Academy of Sciences(Grant No.KSCX2-2-03).

摘　　要：This report describes a new model of emotional stress, which was induced by randomly giving an empty water bottle to rats during watering periods per day for 14 consecutive days. The behavioral, endocrinological and immunological consequences were investigated. The data showed that the emotional stress activated both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, leading to the increased blood levels of corticosterone and catecholamine. It also elicited attacking and exploring behavior, suppressed the immune function of the rats, including leukocyte counts, weight of the spleen, and the level of specific anti-ovalbumin IgG antibody production. Presenting no water and no empty bottle to rats only evoked the exploring behavior, increased the corticosterone level and decreased the leukocyte counts. These findings demonstrate a role of psychological factors on behavioral, endocrinological and immunological functioning. The animal model described in the present study may serve as an analogue mimicking emotional stress experienced in humans (e.g. anger and/or anxiety), and may be useful for further studying the complex relationships among emotional stress, behavior, and immune function.This report describes a new model of emotional stress, which was induced by randomly giving an empty water bottle to rats during watering periods per day for 14 consecutive days. The behavioral, endocrinological and immunological consequences were investigated. The data showed that the emotional stress activated both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, leading to the increased blood levels of corticosterone and catecholamine. It also elicited attacking and exploring behavior, suppressed the immune function of the rats, including leukocyte counts, weight of the spleen, and the level of specific anti-ovalbumin IgG antibody production. Presenting no water and no empty bottle to rats only evoked the exploring behavior, increased the corticosterone level and decreased the leukocyte counts. These findings demonstrate a role of psychological factors on behavioral, endocrinological and immunological functioning. The animal model described in the present study may serve as an analogue mimicking emotional stress experienced in humans (e.g. anger and/or anxiety), and may be useful for further studying the complex relationships among emotional stress, behavior, and immune function.

关 键 词：情绪压力 免疫学 神经内分泌系统 交感神经系统 白血球 身体健康 

分 类 号：B842.6[哲学宗教—基础心理学] R741[哲学宗教—心理学]