宫颈恶性腺瘤6例临床病理分析  

Cervical adenoma malignum: a clinicopathologic analysis of 6 cases

作　　者：宋蔚青[1] 陈晓端[1] 周彩云[1] 赵承洛[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,杭州310006

出　　处：《临床与实验病理学杂志》2003年第4期360-363,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的　探讨宫颈恶性腺瘤 (cervicaladenomamalignum ,CAM)临床病理学特征及早期诊断。 方法　对 6例CAM的临床资料及 3例阳性涂片进行分析 ,选用CEA、c erbB 2、CD4 4v6、Ezrin(p81)和mucin 5种抗体采用二步法进行免疫组化染色。结果　CAM临床表现均有白带大量增多 ,但白带检验结果无异常。 3例细胞学涂片显示特征性图像。CEA在 6例CAM中有阳性表达 ,而在正常宫颈组织中仅 1例表达。其余 4项免疫组化指标对CAM和正常宫颈组织的表达无差异。结论　细胞学检查在CAM早期诊断中有重要意义。CEA阳性对CAM与良性宫颈病变有一定鉴别意义。临床白带长时间大量增多且化验无异常发现时应警惕CAM的可能。Purpose To study the clinicopathologic features and early diagnosis of cervical adenoma malignum(CAM). Methods The medical records and clinicopathologic results of six patients with CAM were reviewed. By using immunohistochemical staining, five antibodies of CEA, c erbB 2, CD44v6, Ezrin (p81) and mucin were chosen. Results Six cases of CAM had leukorrhagia symptom, however, leukorrhagia examination were normal. Three cases of cytological examination were abnormal. CEA was positive in all six CAM cases, but only one normal cervical tissue was positive for CEA. The expressions of the other four markers had no difference between CAM and normal cervical tissue. Conclusions Cytological examination and leukorrhagia symptom are significiant for early diagnosis of CAM. CEA can be used to differential diagnosis between CAM and benign cervical disease.

关 键 词：宫颈恶性腺瘤 CAM 病理学 诊断 细胞学 

分 类 号：R737.33[医药卫生—肿瘤]