尼索地平双层渗透泵片的制备及其体外释放度的考察  

Preparation and in vitro release of nisoldipine two-layer osmotic pump tablets

作　　者：吴学明[1] 聂淑芳[1] 张宁[1] 郑启兰[1] 侯鹏[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国药学杂志》2004年第1期46-48,共3页Chinese Pharmaceutical Journal

摘　　要：目的　对尼索地平双层渗透泵片的处方工艺和体外释放进行研究。方法　以自制片与国外上市缓释片体外释药数据的相似因子为评价指标 ,采用正交设计对处方进行了优化。结果　最优处方组成为 :包衣膜重 2 3.0mg ,氯化钠 13.5mg ,PEO4 4 .5mg。最优处方的 3批样品在 14h内呈现零级释放特征 ,体外释药特征与国外缓释片相似 (f2 =6 8.1)。OBJECTIVE: To study the preparation and drug release of nisoldipine two-layer osomatic pump tablets. METHODS: The optimal formulation was selected by orthogonal design. RESULTS: The preparation had excellent zero-order release profile within 14 hours. CONCLUSION: The drug release profile of the product is similar to that of the foreign products.

关 键 词：尼索地平双层渗透泵片 体外释放度 正交设计 NP 线性关系 

分 类 号：R943[医药卫生—药剂学]