喉癌喉咽癌患者血清NO浓度变化及其临床意义  

The expression and clinical implication of nitric oxide in serum of patients with laryngeal carcinoma or hypopharyngeal carcinoma

作　　者：杜晓东[1] 栾信庸[1] 潘新良[1] 王丰[2] 任金冬[2] 

机构地区：[1]山东大学齐鲁医院 [2]苏州大学附属第四医院

出　　处：《山东医药》2004年第6期14-15,共2页Shandong Medical Journal

摘　　要：目的　研究一氧化氮 (NO)在喉癌喉咽癌血清中的浓度及其临床意义 ,探讨 NO在喉癌喉咽癌肿瘤免疫方面的作用。方法　采用硝酸还原酶法测定 3 0例健康人和 50例喉癌喉咽癌患者血清 NO- 3 和 NO- 2 之和反应体内 NO水平。结果　喉癌喉咽癌患者血清 NO含量显著高于健康人 ,前者为 (12 1.15± 42 .2 9)μmol/ L ,后者仅为 (68.64± 17.3 6)μm ol/ L (P <0 .0 0 1) ,喉癌喉咽癌患者术后 2周的血清 NO含量 (89.97± 3 2 .77)μmol/L ,与术前组比较 ,明显降低 (P <0 .0 0 1) ,有淋巴结转移组 (114 .3 3± 3 0 .2 1)μmol/ L ,显著低于无淋巴结转移组 (12 9.2 3± 2 4.47) μmol/ L,P <0 .0 5。结论　 NO可能在分子水平参与了喉癌喉咽癌的发生。Objective To study the serum l evels of nitric oxide(NO)of patients wit h laryngeal carcinoma of hypopharyngeal carcinoma and its clinical value M ethods The methid of nitrifying fe rment was used to test the serum level o f NO and total concentration of NO - 3 a nd NO - 2 from 30 healthy persons and 50 atients with the laryngeal carinoma or hypopharynge al carcinoma patients Results The serum leve l of NO was higher in the patients[(121± 42 29)μmol/L]than that in the healthy pe r sons[(68 64±17 36)μmol/L] Тhe serum leve l of NO in laryngeal carcinoma was lower[ (89 97±32 77)μmol/L]after operation The s erum level of NO in the lymphnode metast asis group was lower[(114 33±30 21)μmol/ L]than that in the non0metastasis group[ (129 23±24 47)μmol/L],P<0 05 C onclusion NO may play an importan t role in the cour se of laryngeal squamous cell carcinoma

关 键 词：喉癌 喉咽癌 血清 NO浓度 一氧化氮 免疫学 硝酸还原酶法 测定 

分 类 号：R739.6[医药卫生—肿瘤] R730.3[医药卫生—临床医学]