恶性淋巴瘤中EB病毒感染的病例-对照研究  

Case-control study of the infections of Epstein-Barr virus in malignant lymphomas.

作　　者：徐才刚[1] 陈劲松[2] 朱焕玲[1] 姚文秀[3] 郑素萍[1] 吴谨绪[1] 

机构地区：[1]四川大学华西医院,四川成都610041 [2]绵阳市中心医院,四川绵阳621000 [3]四川省肿瘤医院,四川成都610041

出　　处：《四川医学》2004年第3期265-266,共2页Sichuan Medical Journal

摘　　要：目的　探讨四川地区恶性淋巴瘤 (ML)中EB病毒感染的情况及其临床意义。方法　本研究采用以医院为基础的病例 对照研究的设计方案。病例组 :病理检查确诊的结内、外ML 80例。对照组 :同期病理组织活检证实的非肿瘤病例 80例。EB病毒 (EBV)检测用病理组织采用EBER ISH法。结果　EBV阳性率ML组 72 5 % ( 5 8/ 80 ) ,对照组 7.5 %( 6/ 80 ) ,OR =7.2 6,95 %CI :13 .2 76～ 10 6.62 4,P =0 .0 0 0 1。结论　本地区EBV感染与ML发病有明显相关性。Objective To investigate the infectious rate of Epstein-Barr virus(EBV) in malignant lymphomas(ML)and the relationship between the incidence of ML and the infection of EBV in Sichuan province.Methods A hospital-based case-control study was Conducted.Case group was diagnosed as ML by pathological examination,which included 80 patients.Control group was composed of 80 subjects with non-malignant diseases demonstrated by pathological examination at the same time.The EBV was confirmed by the EBER in situ-hybridization of pathological tissue.Results The positive rate of EBV in ML group was 72.5%(58/80)and that of control group was 7.5%(6/80).The difference between these two groups showed a statistical significance by logistic regression analysis(OR=7.26,95%CI:13.276～106.624,P=0.0001).Conclusion The incidence of ML indicates a significant association with the infection of EBV in Sichuan.

关 键 词：恶性淋巴瘤 EB病毒 感染 

分 类 号：R733.1[医药卫生—肿瘤]