病毒唑的合成新工艺  

A New Sythesis of Ribavirin

作　　者：杨宝东[1] 张宏森[1] 

机构地区：[1]哈药集团制药总厂,150086

出　　处：《黑龙江医药》2004年第2期122-123,共2页Heilongjiang Medicine journal

摘　　要：目的:采用合成新工艺提高病毒唑的收率。方法:用肌苷为原料,经乙酰化后在双磷酸酯的作用下与1,2,4-三氮唑-3-羧酸甲酯缩合,再经氨解制得产品。结果:以肌苷计,总收率为48%。结论:该合成路线简单实用,易在生产中推广。Objective:Using the new sythesis of Ribavirin to improve the yield.Method:Ino- sine was acetylated to tetracetylribofuranose,which was condensed with Me 1,2,4-trazole-3-car- boxylate b the aiding of bisphosphate.Then treated with NH_3 to give Ribavirin.Result:The over- all yield was 48% on the basis of inosine.Conclusion:This new synthesis route is simple and use- ful,can be easily realized in the wide production.

关 键 词：病毒唑 合成 新工艺 肌苷 四乙酰核糖 

分 类 号：TQ460.6[化学工程—制药化工]