羧甲基壳聚糖对胆红素的吸附性能研究  

STUDIES ON THE ADSORPTION OF BILIRUBIN IN SOLUTION BY CM-CTS

作　　者：吴刚[1] 沈玉华[1] 谢安建[1] 林宏云[1] 

机构地区：[1]安徽大学化学化工学院,合肥230039

出　　处：《离子交换与吸附》2004年第1期7-12,共6页Ion Exchange and Adsorption

基　　金：国家自然科学基金(20031010;29971001)

摘　　要：合成了不同取代度的羧甲基壳聚糖(CM-CTS)作为吸附剂,研究了不同条件对CM-CTS吸附胆红素性能的影响。结果表明:在实验条件下,随着羧甲基取代度的增加和体系温度的升高,最大吸附率和吸附速率均相应增加;在接近人体血液pH值的条件下,CM-CTS对胆红素的吸附性能较佳;人血清白蛋白和离子强度的增加对CM-CTS吸附胆红素有明显的抑制作用。We synthesized CM-CTS, Which carboxymethylation substitutive degrees were 0.15, 0.1, 0.06, respectively, and were used as adsorbent. The influence of adsorption conditions such as substitutive degrees, temperature, pH value, human serum albumin (HAS) and ionic intensity on CM-CTS抯 adsorbability for bilirubin was studied. The result showed, under the experimental conditions, that CM-CTSs adsorbability enhanced with the substitutive degree increasing and temperature rising. Being close to pH value of blood in the human body. The CM-CTS had good adsorbability for the bilirubin. Obviously, HAS and NaCl inhibited CM-CTS from adsorbing bilirubin.

关 键 词：羧甲基壳聚糖 胆红素 吸附性能 取代度 吸附剂 人工肝 生物相容性 肝功能异常 

分 类 号：R575.3[医药卫生—消化系统]