大肠良恶性病变细胞凋亡与增殖的观察  

The Observation on Apoptosis and Mitosis of Colon Benign and Malignant Lesions

作　　者：张式暖[1] 章爱梅 王艳华[1] 张景玉 孙永红[1] 魏志新[1] 

机构地区：[1]潍坊医学院病理学教研室,山东潍坊261042 [2]坊子人民医院 [3]菏泽市人民医院

出　　处：《潍坊医学院学报》2003年第3期214-215,共2页Acta Academiae Medicinae Weifang

摘　　要：目的　观察凋亡指数 (AI)和分裂指数 (MI)在病变的生物学行为及判断预后中的价值。方法　用62例大肠良恶性病变标本 ,利用图像分析系统 ,观察分析细胞的凋亡指数及分裂指数与病变性质的关系。结果　正常粘膜上皮细胞AI为 5± 1,在浸润性大肠癌病变中AI为 3.4± 1.87。统计学分析处理发现 ,浸润性癌细胞AI显著低于其他病变 (P <0 .0 1) ,而MI显著高于其他病变 (P <0 .0 1) ,表明细胞生长旺盛。结论　提示AI。Objective To observe the value of AI and MI in biological behavior and determining prognosis of lesions. Methods 62 cases with colon benign and malignant lesions were used to observe association of cells AI and MI and lesions characters, making use of MIPS. Results In normal mucosa epithelial cells, AI was 5±1.In invasive carcinomas, AI was 3.4±1.87. AI in invasive carcinomas was much lower and MI was much higher than those in other diseases after statistical analysis(both P<0.01).These results suggest that the cells grow well. Conclusion All these results suggest that AI and MI have certain value in determing the biological behavior and prognosis of the colon diseases.

关 键 词：大肠 良恶性病变 凋亡指数 分裂指数 

分 类 号：R735.34[医药卫生—肿瘤]