小鼠急性重复缺氧后心脏匀浆中出现的一种新物质  

Change of Heart Homogenate in Mice After Acute Repetitive Hypoxia

作　　者：王桥[1] 宋学英[1] 刘永利[1] 吕国蔚[1] 

机构地区：[1]首都医科大学基础医学院

出　　处：《首都医科大学学报》2004年第1期7-8,共2页Journal of Capital Medical University

基　　金：国家自然科学基金 (3 9670 2 71);北京市自然科学基金 (7962 0 0 9)资助项目

摘　　要：对小鼠进行急性重复性缺氧 ,并测定未缺氧小鼠及缺氧小鼠心脏匀浆高效液相色谱图。发现小鼠缺氧后 ,心脏匀浆中出现一种新物质 ,且随小鼠缺氧耐受的增加 ,该物质的生成量增大。提示 :该物质是与缺氧密切相关的物质 ,可能是一种能抵抗缺氧、增强耐受的物质抗缺氧因子 ,也可能是机体在抵抗缺氧过程中产生的代谢产物。The chromatograms of heart homogenate after acute hypoxia in mice were determine d by HPLC. A new compound was found in heart homogenate in mice after hypoxia. A nd the more the tolerant duration increased in mice, the more compounds were pro duced. It was shown the compound was correlative to hypoxia. It may be an antihy poxic factor that can enhance hypoxic tolerance in mice, but it may also be a me tabolite in mice under hypoxia.

关 键 词：急性重复缺氧 心脏匀浆 高效液相色谱 抗缺氧因子 

分 类 号：R364.4[医药卫生—病理学]