上皮性卵巢癌内血管内皮生长因子的表达及微血管密度的病理意义  

The relationship between vascular endothelial growth factor, microvascular density and clinicopathologic study in Primary Epithelial ovarin carcinomas

作　　者：何常[1] 薄丽[1] 钟愉[1] 肖子文[2] 

机构地区：[1]贵阳医学院病理学教研室,550004 [2]贵阳医学院附属医院妇产科,550004

出　　处：《贵州医药》2004年第3期220-221,F002,共3页Guizhou Medical Journal

摘　　要：目的探讨 34例上皮性卵巢癌内血管内皮生长因子 (VEGF)的表达及微血管密度(MVD)的病理意义。方法应用免疫组化SP法对 34例上皮性卵巢癌内血管内皮生长因子 (VEGF)的表达及微血管密度 (MVD)进行检测。结果上皮性卵巢癌内VEGF的阳性表达率为 76 .5 % (2 6 /34) ,VEGF的表达及MVD均与患者网膜或腹股沟淋巴结转移相关 (P <0 .0 5 ) ,FIGO分期中Ⅰ、Ⅱ期患者的VEGF的阳性表达率及MVD显著低于Ⅲ、Ⅳ期患者 (P <0 .0 5 ) ,VEGF的表达及MVD与组织学分级无关 (P >0 .0 5 )。VEGF与MVD间呈正相关关系 (r=0 .70l,P <0 .0 1)。结论上皮性卵巢癌内VEGF的表达及MVD与患者的淋巴结转移、FIGO分期有关。Objective To study the relationship between vascular endothelial growth factor(VEGF),microvascular density(MVD) and clinicopathologic in primary epithelial ovarin carcinoma. Methods The expression of VEGF protein and MVD in 34 cases of primary epithelial ovarin carcinoma were studied by immunohistochemistry of SP.Results The positively rates of VEGF in primary epithelial ovarin carcinoma was 76.5%. Both the expression of VEGF and MVD were correla'ted significantly with lymph node metastasis(P<0.05), The expression of VEGF and MVD of tumor in stage Ⅰ?Ⅱ were significantly lower than that of tumor with stage Ⅲ?Ⅳ(P<0.05). In addition,Between the expression of VEGF and MVD were not related with diffentiation (P>0.05). There was a close positive correlated between VEGF and MVD(r=0.701, P<0.01)Conclusion The expression of VEGF and MVD were correlated significaritly with biological findings in primary epithelial ovarin carcinoma.

关 键 词：上皮性卵巢癌 血管内皮生长因子 VEGF 微血管密度 病理学 基因表达 肿瘤 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]