格拉司琼口服剂型与针剂控制放化疗所致恶心呕吐的效果比较  

A Comparison of oral administration and intravenous infusion of granisetron for prevention of chemotherapy or radiotherapy induced emesis

作　　者：武晓勤[1] 李学[1] 李志宇[2] 刘端祺[2] 刘喆[3] 朱允中[3] 徐丽艳[3] 冯勤付[4] 李晔雄[4] 

机构地区：[1]中日友好医院中医肿瘤科,北京100029 [2]北京军区总医院肿瘤中心,北京100007 [3]北京胸部肿瘤结核病医院肿瘤科,北京101149 [4]中国医学科学院肿瘤医院放疗科,北京100022

出　　处：《中日友好医院学报》2004年第1期10-12,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的 :比较格拉司琼口服剂型与针剂控制放化疗所引起的恶心呕吐副反应的疗效。方法 :将 99例接受放化疗的恶性肿瘤患者按 2 :1的比例随机分为两组 ,口服剂组 6 2例 ,格拉司琼口服剂型胶囊止吐 ;针剂组 37例 ,静脉用格拉司琼针剂止吐。结果 :口服剂组和针剂组的止吐有效率分别为 80 .6 %和 78.4 % ,两组间无显著性差异 (P >0 .0 5 )。两组对急性消化道反应的控制有效率均略高于延迟性反应。不良反应轻微、可耐受。结论 :格拉司琼口服剂型防治放化疗所引起的恶心呕吐副反应 ,疗效与格拉司琼针剂相仿 ,它是针对放化疗患者的安全、有效、相对便宜的预防止吐药。Objective:To compare the antiemetic effectiveness of oral administration and intravenous injection of granisetron for the prevention of nausea and vomiting in patients receiving chemotherapy or radiotherapy.Methods:According to the ratio 2:1, ninety-nine cases of patients with malignant tumors who underwent chemotherapy or radiotherapy were randomized into two groups in a prospective trial. Oral granisetron(Opuding)group contained 62 cases, and intravenous granisetron group contained 37 cases.Results:No significant difference was found between the antiemetic effectiveness between patients receiving oral granisetron(80.6%)and intravenous granisetron(78.4%)( P >0.05). There were better results in the acute digestive side-effects than the delayed digestive side-effects in both groups. The side-effects of the two ways of medication were mild and acceptable.Conlusion:The effect of Oral granisetron(Opuding)is equivalent to intravenous granisetron for relief of chemotherapy or radiotherapy induced nausea and vomiting. Oral granisetron is safe, effective, and relatively inexpensive.

关 键 词：格拉司琼 口服剂型 针剂 控制 化疗 恶心 呕吐 放疗 

分 类 号：R730.5[医药卫生—肿瘤]