7种中药对实验性口腔癌阻断作用的研究  

Intercepting effects of seven Chinese herb drugs on experimental oral carcinogenesis

作　　者：张为新[1] 胡慧芳[1] 李伟国[1] 周曾同[1] 

机构地区：[1]上海第二医科大学附属第九人民医院口腔医学院口腔内科,上海200011

出　　处：《上海口腔医学》2004年第1期34-37,共4页Shanghai Journal of Stomatology

摘　　要：目的:筛选对实验性口腔癌的发生有阻断作用的有效中草药。方法:选用金黄地鼠410只,随机分为阳性对照组、阴性对照组和7个实验组(马尾连,山豆根,山慈菇,石菖蒲,白芷,莪术,瓜蒌)。采用二甲基苯并蒽涂搽颊囊黏膜,诱发金黄地鼠口腔癌,分别用7种中药的水煎液灌胃,干预癌变过程。取颊囊标本行组织病理学观察,研究7种中药对口腔癌发生的阻断作用。结果:山豆根与莪术组动物的颊囊黏膜异常增生发生率明显低于阳性对照组,而其他5组动物的颊囊黏膜的异常增生率与阳性对照组无显著性差异。结论:中药山豆根和莪术对实验性口腔癌的发生有明显的阻断作用。PURPOSE:To screen effective chemopreventive Chinese herb drugs on experimental oral carcinogenesis. METHODS: 410 golden hamsters were randomly divided into positive control group,negative control group and 7 experimental groups(Radix et Rhizoma Thalictri, Radix Sophorae Tonkinesis, Pseudobulbus Cremastrae appendiculate, Rhizoma Acori Tatarinowii, Radix Angelicae seu Heraclei, Rhizoma Curcumae, Fructus Trichosanthis). 7,12-Dimethylbenz(a)anthracene(DMBA) was used to induce oral carcinogenesis in hamster cheek pouch, 7 liquid Chinese herb drugs were respectively injected into the stomach of the hamsters before and during oral carcinogenesis. Specimens were observed by histopathologic method, and the results were analysized statistically . RESULTS: Compared with positive control group, the prevalence of displasia was significantly reduced in group Radix Sophorae Tonkinesis and Radix Angelicae Dahuricae, but significant decrease could not be found in other experiment groups. CONCLUSION: Radix Sophorae Tonkinesis and Radix Angelicae Dahuricae could effectively intercept DMBA-induced oral carcinogenesis in hamster.

关 键 词：中药 实验性口腔癌 化学预防 药物筛选 阻断作用 组织病理学 颊囊黏膜异常增生 

分 类 号：R739.8[医药卫生—肿瘤]