重症卒中患者血清肿瘤坏死因子-α动态变化的研究  

Study on the change of TNF-α in serum of the critical stroke patients

作　　者：俞芃[1] 宿英英[2] 

机构地区：[1]首都医科大学宣武医院神经内科 [2]首都医科大学宣武医院重症监护室,100053

出　　处：《中国脑血管病杂志》2004年第3期125-126,共2页Chinese Journal of Cerebrovascular Diseases

摘　　要：目的 探讨重症脑卒中患者血清肿瘤坏死因子(TNF)-α的动态变化及临床意义。 方法采用放射免疫法测定34例重症卒中患者血清TNF-α在发病后24h、3d、7d、14d的动态变化,并与正常对照组30名健康人进行了比较。 结果 34例患者血清TNF-α含量于24h内显著升高,与正常对照组相比P<0.01。卒中患者TNF-α呈先升高后降低的趋势,7d达到高峰。 结论 TNF-α等细胞因子在脑源性多脏器功能紊乱综合征(MODS)发病过程中起着重要作用,TNF-α水平的变化对MODS的早期预测和干预可能具有重要意义。Objective To study the change and significance of serum TNF-α in critically stroke patients. Methods By using radioimmunoassay (RIA) method, serum TNF-α level was measured in 34 critically stroke patients, and compared with healthy controls. Results Compared with healthy controls within 24h, serum TNF-α level was significantly higher in the stroke patients(P<0. 01) . The TNF-α level continued to increase in the following continuous days and on the 7th day reached the maximum value, then the TNF-α level decreased. Conclusion Cytokmes play an important role in the multi-organ dysfunction syndrome (MODS) which results from stroke. The changes of TNF-α can be used for early MODS prediction and treatment.

关 键 词：重症卒中 血清肿瘤坏死因子-Α 动态变化 脑血管意外 系统性炎症反应综合征 

分 类 号：R743.3[医药卫生—神经病学与精神病学]