新发病的特发性全面强直阵挛发作患者局部脑血流观察  

Observation of Regional Cerebral Blood Flow in New-onset Patients of Idiopathic Generalized Tonic Clonic Seizure

作　　者：王开颜[1] 洪震[1] 吕传真[1] 侯敏[2] 刘兴党[2] 王开颜 洪震[1] 吕传真[1] 侯敏[2] 刘兴党[2] 

机构地区：[1]复旦大学附属华山医院神经科200040 [2]复旦大学附属华山医院核医学科200040

出　　处：《中国临床神经科学》2004年第1期10-12,共3页Chinese Journal of Clinical Neurosciences

基　　金：博士后科学基金资助项目 (编号 2 0 0 30 332 79)

摘　　要：目的 :探讨特发性全面强直阵挛发作 (generalizedtonicclonicseizure ,GTCS)癫患者发作间期局部脑血流 (rCBF)特征。方法 :用单光子发射计算机断层显像 ( 99Tcm ECD SPECT)技术对 2 0例新发病的特发性GTCS患者发作间期rCBF特征进行观察 ,以兴趣区(ROI)法作半定量分析。结果 :2 0例新发病的特发性GTCS患者发作间期rCBF异常率为 3 0 % ( 6例 ) ,主要表现为一侧丘脑区或基底节区的放射性稀疏。结论 :新发病的特发性GTCS患者的rCBF存在两种特征 :①正常的CBF ;②一侧丘脑区CBF降低 。Aim:To study the difference of regional cerebral blood flow (rCBF) in new-onset patients of idiopathic generalized tonic clonic seizure (GTCS).Methods:Interictal rCBF measurements using 99Tc m-ethyl cysteinates dimer (ECD) SPECT was performed on 20 new-onset idiopathic GTCS patients.The rCBF distribution was semi-quantitatively analyzed by regions of interest (ROIs).Results:The abnormal rate of hypoperfusion rCBF in new-onset patients with idiopathic GTCS was higher than that of age-matched healthy persons significantly (P<0.05).ROI analysis showed that 30% of new-onset patients with idiopathic GTCS had interictal hypoperfusion rCBF in basal ganglia or thalamus.Conclusion:Our results demonstrated that there are two kinds of condition of the interictal hypoperfusion rCBF in the new-onset idiopathic GTCS:one is normal;the other is the hypoperfusion rCBF of thalamus.

关 键 词：新发病 特发性全面强直阵挛 局部脑血流 脑灌注显像 半定量分析 

分 类 号：R743[医药卫生—神经病学与精神病学]