中药合剂在大鼠烧伤炎症反应中的作用  

Effect of Chinese traditional medicine mixture on inflammatory response in rats with severe burn

作　　者：罗成群[1] 周建大[1] 陈道谨[1] 贺全勇[1] 朱利军[1] 李高峰[1] 李萍[1] 周鹏翔[1] 石光清[1] 

机构地区：[1]中南大学湘雅三医院烧伤整形科,长沙410013

出　　处：《中南大学学报（医学版）》2004年第1期32-34,共3页Journal of Central South University ：Medical Science

基　　金：湖南省科技厅立项课题;湖南省卫生厅中医药科研基金 (2 0 3 2 8;2 0 2 2 66)

摘　　要：目的 :探讨中药合剂对烧伤炎症反应的调理作用。方法 :SD大鼠 110只随机分为对照组、烫伤组和烫伤后中药合剂喂服组 (中药组 ) ,烫伤组和中药组制备成III度 30 %总体表面积烫伤模型 ;采用放射免疫法 ,分别于伤后 6h ,1,5 ,10 ,2 0d时检测大鼠血清TNF α,IL 1β ,IL 6 ,IL 8,IL 4和IL 10含量。结果 :烫伤组和中药组血清中各指标伤后明显升高 ,中药组促炎因子 (TNF α ,IL 1β ,IL 6 ,IL 8)分别在不同时相点低于烫伤组 ,而抗炎因子 (IL 4 ,IL 10 )分别在不同时相点高于烫伤组。结论 :中药合剂对烧伤炎症反应具有明显调理作用 。Objective To investigate the regulatory effect of Chinese traditional medicine mixture (CTMM) on inflammatory response in rats with severe burn.Methods One hundred and ten rats were randomly divided into 3 groups:scalded rats inflicted by 30% III degree scald were treated with CTMM and SD-Ag (CTMM group), scalded rats inflicted by 30% III degree scald were treated with SD-Ag alone (scalded group), and healthy rats were treated with SD-Ag (normal group). The serum contents of TNF-α, IL-1β, IL-6, IL-8, IL-4,and IL-10 in rats in the 3 groups were dynamically monitored.Results The serum contents of TNF-α, IL-1β, IL-6, IL-8, IL-4,and IL-10 evidently increased in both the CTMM and scalded groups. But the contents of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) in the CTMM group were much lower than those in the scalded group. However, the contents of anti-inflammatory cytokines ( IL-4 and IL-10 ) in the CTMM group were much higher than those in the scalded group.Conclusion CTMM has double-way regulatory effect on the inflammatory response in rats with severe burn.

关 键 词：中药合剂 大鼠 烧伤 炎症反应 细胞因子 全身性炎症反应综合症 放射免疫法 清火败毒饮方 

分 类 号：R269[医药卫生—中西医结合]