癫痫患者血浆及红细胞中抗氧化剂水平的测定  

Determination of antioxidants in plasma and erythrocyte in patients with epilepsy

作　　者：廖可宏[1] 梅其元[2] 周有才[3] 

机构地区：[1]中南大学湘雅二医院检验科,长沙410011 [2]中南大学湘雅二医院精神科,长沙410011 [3]中南大学湘雅二医院药剂科,长沙410011

出　　处：《中南大学学报（医学版）》2004年第1期72-74,共3页Journal of Central South University ：Medical Science

摘　　要：目的 :探讨癫痫疾病状态下血浆及红细胞 (RBC)中抗氧化剂水平的变化。方法 :测定 39例正常对照组、32例癫痫疾病组和 2 6例癫痫治疗组的RBC内谷胱甘肽还原酶 (GR)、谷胱甘肽过氧化物酶 (GSH Px)、超氧化物歧化酶 (SOD)和过氧化氢酶 (CAT)、红细胞膜过氧化脂质代谢产物丙二醛 (MDA)、红细胞溶血百分率以及血浆中铜蓝蛋白 (CER)、维生素A ,C ,E(VitA、VitC、VitE)等。结果 :疾病组的红细胞MDA ,溶血百分率 ,GSH Px ,CAT及血浆CER显著高于对照组 (P <0 .0 5 ) ,红细胞GR、SOD和血浆VitA ,VitC ,VitE显著低于对照组 (P <0 .0 5 ,其中红细胞GR ,血浆维生素C ,P <0 .0 1) ;治疗组的红细胞GR ,SOD ,血浆VitC ,VitE均显著高于疾病组 (P <0 .0 5 ,其中GR ,P <0 .0 1)。结论Objective To explore the changes of antioxidants in plasma and erythrocyte in epileptic patients.Methods The levels of erythrocyte enzymes glutathione reductase (GR), glutathione peroxidase (GSH-Px),superoxide dismutase (SOD),catalase and erythrocyte membrane lipid peroxidation (MDA), the percentage hemolysis, and plasma ceruloplasmin, vitamin A, vitamin C, vitamin E were measured in 39 controls, 32 epileptic patients and 26 follow-up patients.Results The levels of MDA, the percentage hemolysis, GSH-Px, CAT and plasma CER in the epileptic patients were significantly higher than those of the controls. While the levels of vitamin A, vitamin C, vitamin E, SOD and GR in the epileptic patients were markedly lower than those of controls. In the follow-up patients, the levels of GR, SOD, vitamin C and vitamin E were significantly higher than those of the epileptic patients.Conclusion Free radicals and antioxidants play important roles in the etiology of epilepsy.

关 键 词：癫痫 血浆 红细胞 抗氧化剂 自由基 氧化损伤 炎症反应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]