内脏痛觉的病理生理研究进展  

Advances in pathophysiological research on visceral pain

作　　者：荣培晶[1] 张建梁[2] 张宏启[3] 

机构地区：[1]北京中医药大学病理学教研室,北京100029 [2]中国中医研究院针灸研究所,北京100700 [3]香港浸会大学中医药学院

出　　处：《中国病理生理杂志》2004年第3期475-480,共6页Chinese Journal of Pathophysiology

基　　金：香港研究资助局(CERG-HKBU2093/01M);国家"九五"攀登预选项目(95JL002)

摘　　要：古人在两千多年前就已提出体表和内脏相联系的观点.<灵枢>早已提到"十二经脉者,内属于脏腑,外络于肢节".中医学认为穴位是脏腑经过经络之气输注于体表的特定部位.它既是脏腑疾病在体表的反应点,又是针刺时疏通气血,调整脏腑功能的激发点.至于内脏-体表相关的具体作用机理,虽有许多未解之迷,但近年来也有不少新进展.本文将集中讨论有关内脏痛的几个关键问题,尤其是中枢传导通路、牵涉痛机理、内脏与体表在中枢神经中的联系、传统疗法的可能作用机制等,并着重介绍这方面研究的一些新发现,希望起到穿针引线,融汇中西的作用,为痛觉研究与病理生理的教学提供一些新的理念与平台.Classical description of central pathways has been that there are segregated routes for visceral and somatic inputs, for pain and tactile processing. Ample evidence in recent studies however calls for a revision of this traditional view. It has been demonstrated that visceral nociceptive inputs may travel in the dorsal column-medial lemnicus system along with skin tactile inputs, and convergence and interactions between the two distinct modalities have been demonstrated in route to the high brain centers. In the spinal cord and thalamus, skin inputs may inhibit noxious colorectal inputs; on the other hand pre-existing visceral nociception may cause abnormally high discharge of single neurons. These recent findings shine light on mechanisms of central processing of visceral nociception and its associated allodynia and referred pain, as well as for the effects of some traditional therapies such as acupuncture and massage.

关 键 词：内脏 疼痛 体躯-内脏相关 

分 类 号：R363[医药卫生—病理学]