神经肽Y在癫痫发病机制中的作用  

Research progress in neuropeptide Y and epilepsy

作　　者：何展文[1] 罗向阳[1] 

机构地区：[1]中山大学孙逸仙纪念医院儿科,广东广州510120

出　　处：《中国病理生理杂志》2004年第3期489-492,共4页Chinese Journal of Pathophysiology

摘　　要：神经肽Y(neuropeptide Y,NPY),即神经肽酪氨酸,是Tatemoto等[1]在1982年首先从猪脑中提取的,基分子含有5个氨基酸残基.Neuropeptide Y (NPY) is a pancreatic polypeptide-related peptide, consisting of 36 amino acids. NPY is expressed in the nervous system widely and abundantly, mainly in the hippocampus, regulates the excitability of neurons through its receptors (Y_1, Y_2, Y_5). In recent years the research progress indicated the changes induced by seizures in the level and distribution of NPY, its receptors subtypes and their respective mRNAs in brain. The inhibitory action of NPY on glutamate-mediated neurotransmission and in seizure phenomena, suggests that one of its roles in hippocampal physiology is to modulate neuronal excitability by regu-lating glutamate release.

关 键 词：受体 神经肽Y 癫痫 谷氨酸 

分 类 号：R749.17[医药卫生—神经病学与精神病学]