60例帕金森病患者抑郁及其相关因素的研究  

Studies on relationship between depression and correlated factors in Parkinson′s disease

作　　者：田国强[1] 胡绍林[1] 吴承龙[2] 杨峰[2] 秦国兴[1] 

机构地区：[1]浙江省绍兴市第七人民医院,312000 [2]浙江省绍兴市人民医院

出　　处：《中国全科医学》2004年第5期319-320,共2页Chinese General Practice

摘　　要：目的　研究帕金森病 (PD)患者的抑郁症状及其相关因素。方法　采用汉密尔顿抑郁量表 (HAMD)与简易精神状态检查量表 (MMSE)调查 6 0例PD患者的抑郁状态及认知功能。结果　病程 >5年者抑郁发生率与病程≤ 5年者抑郁发生率间差异有显著性意义 (P <0 0 1) ;Hoehn-YahrⅠ、Ⅱ期患者抑郁发生率与Ⅲ期以上患者抑郁发生率间差异有显著性意义 (P <0 0 1) ;抑郁患者MMSE得分与无抑郁者间差异有显著性意义 (P <0 0 1)。结论　PD患者有较高的抑郁发生率 ,与PD病程、病情分期。Objective To study the depression and correlated factors of patents with Parkinson′s disease (PD).Methods 60 patients′ depression and cognitive ability were assessed by Hamilton Depression Rating Scale(HAMD) and Mini-Mental State Examination(MMSE).Results Incidence of depression in PD patients(46 7%)was higher than that of controls (7 5%).There was significant difference between the occurrence of depression in the PD patients whose duration were over 5 years and below 5 years.There was significant difference between depression patients inⅠ,Ⅱ stage of Hoehn-Yahr and ones over Ⅲ stage (P<0 01);the scores of MMSE in depression patients were lower than those of no depression(P<0 001).Conclusion There is high incidence of depression in PD patients.The severity degree of depression is associated with duration,course of disease and cognitive function.

关 键 词：帕金森病 相关因素 抑郁症状 汉密尔顿抑郁量表 

分 类 号：R742.5[医药卫生—神经病学与精神病学]