精神分裂症患者局部脑血流研究  

The regional cerebral blood flow of schizophrenic by ^(99m )Tc-ECD brain SPECT imaging

作　　者：郑洪波[1] 殷青云[1] 余金龙[1] 钟潇琦[1] 李含秋[1] 朱海兵[1] 潘小平[2] 

机构地区：[1]广东广州市精神病医院,510370 [2]广州市第一人民医院

出　　处：《临床精神医学杂志》2004年第2期65-67,共3页Journal of Clinical Psychiatry

基　　金：广东省医学科学技术研究基金项目 (A19985 5 3 )

摘　　要：目的 :了解精神分裂症患者局部脑血流 (rCBF)特征 ,探讨rCBF与临床症状和疗效的关系。　方法 :采用阳性症状与阴性症状量表 (PANSS)评定精神分裂症患者精神症状 ,应用99m锝 双半胱乙脂(99mTc ECD) ,单光子发射计算机断层扫描 (SPECT)技术 ,测量患者治疗前后rCBF ,并与 11名正常人作对照。　结果 :治疗前患者组右侧额叶与右侧颞叶rCBF低于对照组 ;治疗后右侧额叶与右侧颞叶rCBF较治疗前明显增加。治疗前不同脑区rCBF与精神病理症状和疗效均无显著相关。　结论 :精神分裂症患者存在右侧额叶与颞叶局部脑功能减退 ,但未发现rCBF与精神病理症状和疗效有关。Objective:To investigate the regional cerebral blood flow (rCBF) in schizophrenic patients and the relationship between rCBF ratio and the symptoms,efficacy. Method:Brain imaging with 17 schizophrenic patients were conducted with 99m Tc-ECD before and after the treatment,and compared with 11 normal controls.Psychiatric symptoms of all patients were evaluated by PANSS. Results:Before treatment,the baseline rCBF of right frontal and trmporal lobes were lower in schizophrenia than in controls.After treatment,rCBF of these two brain regions in schizophrenia were improved significantly.No significant correlation was found between rCBF in different brain regions and psychopathologic symptoms and efficacy. Conclusion:The function of right frontal and temporal lobes decrease in schizophrenia, but there is no significant correlation between rCBF and mental symptoms ,efficacy.

关 键 词：精神分裂症 单光子发射计算机断层扫描 局部脑血流 

分 类 号：R749.3[医药卫生—神经病学与精神病学]