丙戊酸钠治疗迟发性运动障碍的双盲对照研究  

A double-blind comparative study of sodium valproate in treating of TD

作　　者：尹秀如[1] 谢宝钦[1] 蒋龙[1] 武浩然[1] 李志文[1] 张东坡[1] 张玉英[1] 王克强[1] 刘秀丽[1] 赵淑霞[1] 刘珍[1] 霍绪平[1] 高顺卿[1] 

机构地区：[1]河北省荣军医院,保定071100

出　　处：《临床精神医学杂志》2004年第2期92-93,共2页Journal of Clinical Psychiatry

摘　　要：目的 :探讨丙戊酸钠治疗抗精神病药所致迟发性运动障碍 (TD)的疗效及安全性。　方法 :对 80例长期服用抗精神病药治疗且符合TD诊断标准的男性精神分裂症患者 ,随机分为治疗组和对照组 ,分别给予丙戊酸钠和安慰剂治疗。采用异常不自主运动量表 (AIMS)和简明精神病评定量表 (BPRS)及副反应量表 (TESS)在治疗前及治疗后 1、2、4、6周末分别评定疗效及不良反应。　结果 :治疗组于治疗后 4周AIMS评分有显著下降 ,治疗后 6周较对照组显著为低。有效率 6 4 1% ,显著较对照组的2 5 0 %为高。　结论 :丙戊酸钠治疗抗精神病药所致TD有效 ,但以低剂量为宜 。Objective:To explore the effect and security of sodium valproate in the treatment of TD caused by antipsychotics. Method:80 male inpatients who met with the criteria of schizophrenia and TD were divided randomly into sodium valproate group and the control group with placebo. The efficacy and safety were assessed with AIMS,BPRS and TESS at the end of week 1,2,4 and 6. Results:The validity rates of sodium valproate group and the control group were 64.1% and 25.0% respectively. The scores of AIMS were significantly lower in sodium valproate group than that in controls at the end of week 6( P <0.01). Conclusion: Lower dose sodium valproate is effective in the treatment of TD caused by antipsychotics. Close attention should be paid to the platelet count.

关 键 词：丙戊酸钠 迟发性运动障碍 

分 类 号：R749.053[医药卫生—神经病学与精神病学]